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Synthesis and anticoagulant function of heparin containing block copolymers on polystyrene microspheres

Creator:

Fry, Allyson Kaye

Abstract:

Contact of blood with the surfaces of synthetic materials is associated with spontaneous protein adsorption, initiating platelet aggregation, the coagulation cascade, and the eventual development of a stable clot. Current therapy to inhibit implant-induced thrombosis is life-long administration of systemic anticoagulants. An alternative to the systemic administration of anticoagulant drugs...

Resource Type:

Masters Thesis

Full Text:

not have been so enjoyable were it not for my best friends, Debbie Gale and Jake Windsor. Debbie
Synthesis and function of bioactive, block copolymer surfactant constructs as relevant to the preparation of anticoagulant and antibacterial medical implant surfaces.

Creator:

Joshi, Pranav R.

Abstract:

Nisin, an antibacterial peptide proven to be an effective inhibitor of Gram-positive bacteria, was incorporated into novel block copolymer constructs and tested for retained antibacterial activity. Covalent coupling was achieved by chemical modification of the N-terminal isoleucine to introduce a thiol group. Thiolated nisin derivatives were then linked to poly[ethylene...

Resource Type:

Dissertation

Full Text:

to fellow graduate students Dr. Carlos Cruz-Fierro, Erik Muehlenkampf, Debbie Gale, Tavi Cruz and