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Filtering by: Creator Loughborough, W. Karl Remove constraint Creator: Loughborough, W. Karl Advisor Mcguire, Joseph Remove constraint Advisor: Mcguire, Joseph Resource Type Masters Thesis Remove constraint Resource Type: Masters Thesis

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  • Synthesis and evaluation of PEO-coated materials for microchannel-based hemodialysis

    Creator:
    Heintz, Keely
    Abstract:
    The marked increase in surface-to-volume ratio associated with microscale devices for hemodialysis leads to problems with hemocompatibility and blood flow distribution that are more challenging to manage than those encountered at the conventional scale. In this work, stable surface modifications with pendant polyethylene oxide (PEO) chains were produced on polycarbonate...
    Resource Type:
    Masters Thesis
    Full Text:
    learning experience! Thanks to my second-in-line (but not least!) advisor Dr. Karl “Rat” Schilke for

  • Retention of protein repulsive character and antimicrobial activity of PEO brush layers following nisin entrapment

    Creator:
    Auxier, Julie A.
    Abstract:
    Nisin, an amphiphilic, antimicrobial peptide, has been shown to integrate into the hydrophobic inner region of poly(ethylene oxide) (PEO) brush layers; however, the presence of integrated nisin may compromise the protein repulsive character of the PEO layer. In particular, the introduction of fibrinogen to nisin-loaded brush layers has been observed...
    Resource Type:
    Masters Thesis
    Full Text:
    all his guidance and support. I also extend my sincere gratitude to Dr. Karl Schilke, who I will

  • Quantifying nisin adsorption behavior at pendant polyethylene oxide brush layers

    Creator:
    Dill, Justen K.
    Abstract:
    A more quantitative understanding of peptide loading and release from polyethylene oxide (PEO) brush layers will provide direction for development of new strategies for drug storage and delivery. The antimicrobial peptide nisin shows potent activity against Gram-positive bacteria including the most prevalent implant-associated pathogens, its mechanism of action minimizes the...
    Resource Type:
    Masters Thesis
    Full Text:
    be learned in a laboratory. My sincere appreciation goes out to Dr. Karl Schilke who was absolutely

  • Nisin adsorption to PEO-PPO-PEO tri-block copolymer layers and its resistance to elution by fibrinogen

    Creator:
    Ryder, Matthew P.
    Abstract:
    While hydrophobic surfaces coated with the poly[ethylene oxide]-poly[propylene oxide]-poly[ethylene oxide] (PEO-PPO-PEO) surfactant Pluronic® F108 are highly resistant to plasma protein adsorption, the antimicrobial peptide nisin has been observed to adsorb in multilayer quantities at such surfaces, and the PEO chains themselves suggested to inhibit nisin exchange by blood proteins. But...
    Resource Type:
    Masters Thesis
    Full Text:
    may never have found my passion. I would also like to say thank you to Karl "Rat" Schilke, who was