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Filtering by: Creator Wallace, Joe D. Remove constraint Creator: Wallace, Joe D. Advisor Mcguire, Joseph Remove constraint Advisor: Mcguire, Joseph

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  • β-Lactoglobulin adsorption equilibrium at low- and high-energy surfaces

    Creator:
    Al-Malah, Kamal Issa Masoud
    Abstract:
    Ellipsometry was used to study the effects of surface energetics and temperature on the equilibrium adsorptive behavior exhibited by β-lactoglobulin. β-Lactoglobulin isotherms at 25, 37, and 55°C were constructed for this purpose. The surfaces of acrylic, polycarbonate, polyester, glass, and #304 stainless steel were contacted with protein solutions of varying...
    Resource Type:
    Masters Thesis
    Full Text:
    Science in Chemical Engineering Presented on February 7. 1991 Title: D-Lactoglobulin Adsorption

  • Molecular origins of peptide entrapment in polyethylene oxide layers

    Creator:
    Wu, Xiangming
    Abstract:
    A more quantitative understanding of peptide entrapment and elution from otherwise protein-repellent polyethylene oxide (PEO) brush layers will provide direction for development of new strategies for drug storage and delivery. Here we describe criteria for peptide integration and structural change within the PEO brush, and discuss the reversibility of peptide...
    Resource Type:
    Dissertation
    Full Text:
    nanoparticles. UV spectroscopy and a quartz crystal microbalance with dissipation monitoring (QCM-D) were used

  • Binding of bacterial lipopolysaccharide by the cationic amphiphilic peptide WLBU2 at interfaces

    Creator:
    Ryder, Matthew P.
    Abstract:
    Passage of blood through a sorbent device for removal of bacteria and endotoxin by specific binding with immobilized, membrane-active, bactericidal peptides holds promise for treating severe blood infections. Peptide insertion in the target membrane and stable binding is desirable, while membrane disruption and release of degradation products to the circulating...
    Resource Type:
    Dissertation
    Full Text:
    ...................................................................... 68 Surface Modification of QCM-D sensors

  • Interaction of recombinant factor VIII and the nonionic surfactant Tween 80 at interfaces

    Creator:
    Joshi, Omkar
    Abstract:
    The role of the nonionic surfactant Tween 80 on the behavior of the therapeutic recombinant protein Factor VIII (rFVIII) was investigated at solid/liquid and air/water interfaces. In order to provide a model system to compare results obtained for the complicated rFVIII-Tween system, a well-characterized globular protein lysozyme was used. The...
    Resource Type:
    Dissertation
    Full Text:
    man I have had the privilege of working with during my graduate studies. Joe McGuire has been, and

  • Functionalization of Surfaces with Nisin in a Polyethylene Oxide Brush Layer

    Creator:
    Ryder, Matthew P.
    Abstract:
    Infections in hospitals account for over 100,000 deaths per year. These infections occur at the hospital from complications following bacterial adhesion to intravenous catheters, coronary stents and other implanted devices. Another common problem is protein adsorption to the surface of the device and subsequent blood clotting. Methods for combating these...
    Resource Type:
    Honors College Thesis
    Full Text:
     grateful.  Joe is my  mentor for this project and my continuing graduate work surrounding this subject

  • Nisin adsorption and function at hydrophobic surfaces coated with the poly[ethylene oxide]-poly[propylene oxide]-poly[ethylene oxide] triblock surfactant Pluronic® F108

    Creator:
    Tai, Yuan-Ching
    Abstract:
    The adsorption and elution of the antimicrobial peptide nisin at hydrophobic, silanized silica surfaces coated with the poly[ethylene oxide]-poly[propylene oxide]- poly[ethylene oxide] surfactant Pluronic® F108 was measured in situ, with ellipsometry. While such layers are known to inhibit protein adsorption, nisin was observed to adsorb in multilayer quantities, to an...
    Resource Type:
    Dissertation
    Full Text:
    life too. There were ups and downs during the years. No matter what happened, Joe always had this

  • Molecular origins of peptide entrapment within polyethylene oxide brush layers

    Creator:
    Lampi, Marsha C.
    Abstract:
    Effective surface coatings for tissue-contacting medical devices should prevent both biofilm formation and infection. One method to achieve this aim is protein repellant polyethylene oxide (PEO) brush coatings loaded with antimicrobials. Previous research has demonstrated that the antimicrobial nisin adsorbs to PEO brush layers in multi-layer amounts and suggests that...
    Resource Type:
    Honors College Thesis
    Full Text:
    ACKNOWLEDGEMENTS I am extremely thankful for the guidance provided by my mentor, Dr. Joe McGuire, to

  • The Role of Syndecan-1 in Arterial Mechanotransduction

    Creator:
    Steyer, Benjamin G.
    Abstract:
    Hemodynamic forces regulate vascular homeostasis and arterial structure through mechanical stimuli by a process called mechanotransduction. Cellular response to mechanical forces involves coordination between cell surface receptors and intracellular signaling pathways. While previous work has focused on the role of integrin receptors in mechanotransduction, little is known about the role...
    Resource Type:
    Honors College Thesis
    Full Text:
    thanks are due to Dr. Joe McGuire for his guidance, mentoring, and relentless dedication to my

  • The Role of Syndecan-1 in Arterial Mechanotransduction.

    Creator:
    Steyer, Benjamin G.
    Abstract:
    Hemodynamic forces regulate vascular homeostasis and arterial structure through mechanical stimuli by a process called mechanotransduction. Cellular response to mechanical forces involves coordination between cell surface receptors and intracellular signaling pathways. While previous work has focused on the role of integrin receptors in mechanotransduction, little is known about the role...
    Resource Type:
    Honors College Thesis
    Full Text:
    thanks are due to Dr. Joe McGuire for his guidance, mentoring, and relentless dedication to my

  • Synthesis and anticoagulant function of heparin containing block copolymers on polystyrene microspheres

    Creator:
    Fry, Allyson Kaye
    Abstract:
    Contact of blood with the surfaces of synthetic materials is associated with spontaneous protein adsorption, initiating platelet aggregation, the coagulation cascade, and the eventual development of a stable clot. Current therapy to inhibit implant-induced thrombosis is life-long administration of systemic anticoagulants. An alternative to the systemic administration of anticoagulant drugs...
    Resource Type:
    Masters Thesis
    Full Text:
    . _____________________________________________________________________ Allyson Kaye Fry, Author ACKNOWLEDGEMENTS My sincere gratitude goes to Dr. Joe