Index Catalog // ScholarsArchive@OSU

Quantification of fibrinogen adsorption to nisin-loaded polyethylene oxide layers

Creator:: Auxier, Julie A.
Abstract:: Antimicrobial coatings used to reduce the risk of infection caused by tissue-contacting medical devices must address specific biocompatibility requirements including prevention of thrombosis and rise of bacterial resistance. An antimicrobial-loaded poly(ethylene-oxide) (PEO) coating has been tentatively shown to be non-fouling with sustained antimicrobial activity. However, the presence of the antimicrobial,...
Resource Type:: Honors College Thesis
Full Text:: -Ching, Joseph McGuire, Jennifer A. Neff. “Nisin antimicrobial activity and structural characteristics

Retention of protein repulsive character and antimicrobial activity of PEO brush layers following nisin entrapment

Creator:: Auxier, Julie A.
Abstract:: Nisin, an amphiphilic, antimicrobial peptide, has been shown to integrate into the hydrophobic inner region of poly(ethylene oxide) (PEO) brush layers; however, the presence of integrated nisin may compromise the protein repulsive character of the PEO layer. In particular, the introduction of fibrinogen to nisin-loaded brush layers has been observed...
Resource Type:: Masters Thesis
Full Text:: environment and even more fortunate to have Dr. Joseph McGuire for a mentor. Dr. McGuire has served as my

Use of contact angle analysis for the measurement of the relative hydrophilicity of food contact surfaces

Creator:: Kirtley, Sidney A.
Resource Type:: Masters Thesis
Full Text:: AN ABSTRACT OF THE THESIS OF Sidney A. Kirtley for the degree

Surface tension kinetics of the wild type and four synthetic, structural stability mutants of bacteriophage T4 lysozyme at the air-water interface

Creator:: Wang, Jun, 1968-
Abstract:: Surface tension kinetics exhibited by selected stability mutants of T4 lysozyme at the air-water interface were monitored with DuNoüy tensiometry. Mutant lysozymes were produced by substitution of isoleucine at position 3 with cysteine, leucine, tryptophan and glycine. Each substitution resulted in an altered structural stability quantified by a change in...
Resource Type:: Masters Thesis
Full Text:: stability quantified by a change in the free energy of unfolding. At a bulk concentration of 1.0 mg/ml

Functionalization of Surfaces with Nisin in a Polyethylene Oxide Brush Layer

Creator:: Ryder, Matthew P.
Abstract:: Infections in hospitals account for over 100,000 deaths per year. These infections occur at the hospital from complications following bacterial adhesion to intravenous catheters, coronary stents and other implanted devices. Another common problem is protein adsorption to the surface of the device and subsequent blood clotting. Methods for combating these...
Resource Type:: Honors College Thesis
Full Text:: , and Dr. Joseph McGuire, whose friendship and guidance will assuredly be a significant influence on

Adsorption of the wild type and a synthetic structural stability variant of bacteriophage T4 lysozyme

Creator:: Podhipleux, Nilobon
Resource Type:: Dissertation
Full Text:: the Wild Type and a Synthetic Structural Stability Variant of Bacteriophage T4 Lysozyme. Abstract

Molecular Origins of Recombinant Factor VIII (rFVIII)

Creator:: Tadehara, Katherine M.
Abstract:: The capability of Pluronic® F68 to stabilize human recombinant Factor VIII in solution was assessed using zeta potential measurements. Hemophilia A is a genetic disorder in which the body is missing Factor VIII (FVIII) from the blood coagulation cascade. The pharmaceutical industry developed recombinant Factor VIII (rFVIII), the largest cloned...
Resource Type:: Honors College Thesis
Full Text:: Katherine M. Tadehara A PROJECT Submitted to Oregon State University University

Nisin adsorption to PEO-PPO-PEO tri-block copolymer layers and its resistance to elution by fibrinogen

Creator:: Ryder, Matthew P.
Abstract:: While hydrophobic surfaces coated with the poly[ethylene oxide]-poly[propylene oxide]-poly[ethylene oxide] (PEO-PPO-PEO) surfactant Pluronic® F108 are highly resistant to plasma protein adsorption, the antimicrobial peptide nisin has been observed to adsorb in multilayer quantities at such surfaces, and the PEO chains themselves suggested to inhibit nisin exchange by blood proteins. But...
Resource Type:: Masters Thesis
Full Text:: approved: ________________________________________________________________________ Joseph McGuire

Structural stability effects on adsorption of bacteriophage T4 lysozyme to colloidal silica

Creator:: Tian, Minghua
Abstract:: Circular dichroism (CD) spectra were obtained for bacteriophage T4 lysozyme and three of its mutants in the presence and absence of colloidal silica nanoparticles. Mutant lysozymes were produced by substitution of the isoleucine at position 3 with tryptophan, cysteine and leucine. Each substitution resulted in an altered structural stability, quantified...
Resource Type:: Masters Thesis
Full Text:: structural stability, quantified by a difference in free energy of unfolding from the wild type. CD spectra

Elution of adsorbed proteins at hydrophobic and hydrophilic surfaces by dodecyltrimethylammonium bromide and sodium dodecyls sulfate

Creator:: Vinaraphong, Pravina
Abstract:: Adsorption kinetic data recorded for α-lactalbumin, β-casein, β-lactoglobulin, bovine serum albumin and lysozyme at silianized silica surfaces of low and high hydrophobicity, along with a simple model for adsorption and surfactant-mediated elution of protein, were used to analyze the removal of each protein by sodium dodecylsulfate (SDS) and dodecyltrimethylammonium bromide...
Resource Type:: Masters Thesis
Full Text:: Dodecyls Sulfate Abstract approved: -i—*■*=—i- "t Joseph McGuire Adsorption kinetic data recorded

ScholarsArchive@OSU

Quantification of fibrinogen adsorption to nisin-loaded polyethylene oxide layers

Retention of protein repulsive character and antimicrobial activity of PEO brush layers following nisin entrapment

Use of contact angle analysis for the measurement of the relative hydrophilicity of food contact surfaces

Surface tension kinetics of the wild type and four synthetic, structural stability mutants of bacteriophage T4 lysozyme at the air-water interface

Functionalization of Surfaces with Nisin in a Polyethylene Oxide Brush Layer

Adsorption of the wild type and a synthetic structural stability variant of bacteriophage T4 lysozyme

Molecular Origins of Recombinant Factor VIII (rFVIII)

Nisin adsorption to PEO-PPO-PEO tri-block copolymer layers and its resistance to elution by fibrinogen

Structural stability effects on adsorption of bacteriophage T4 lysozyme to colloidal silica

Elution of adsorbed proteins at hydrophobic and hydrophilic surfaces by dodecyltrimethylammonium bromide and sodium dodecyls sulfate

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