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Filtering by: Creator Michel, Alexa K. Remove constraint Creator: Michel, Alexa K. Advisor Mcguire, Joseph Remove constraint Advisor: Mcguire, Joseph

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  • The Role of Syndecan-1 in Arterial Mechanotransduction

    Creator:
    Steyer, Benjamin G.
    Abstract:
    Hemodynamic forces regulate vascular homeostasis and arterial structure through mechanical stimuli by a process called mechanotransduction. Cellular response to mechanical forces involves coordination between cell surface receptors and intracellular signaling pathways. While previous work has focused on the role of integrin receptors in mechanotransduction, little is known about the role...
    Resource Type:
    Honors College Thesis
    Full Text:
    . Secondary antibodies labeled with Alexa Fluor 594 or 488 (Invitrogen) were added and samples were

  • The Role of Syndecan-1 in Arterial Mechanotransduction.

    Creator:
    Steyer, Benjamin G.
    Abstract:
    Hemodynamic forces regulate vascular homeostasis and arterial structure through mechanical stimuli by a process called mechanotransduction. Cellular response to mechanical forces involves coordination between cell surface receptors and intracellular signaling pathways. While previous work has focused on the role of integrin receptors in mechanotransduction, little is known about the role...
    Resource Type:
    Honors College Thesis
    Full Text:
    . Secondary antibodies labeled with Alexa Fluor 594 or 488 (Invitrogen) were added and samples were

  • Retention of protein repulsive character and antimicrobial activity of PEO brush layers following nisin entrapment

    Creator:
    Auxier, Julie A.
    Abstract:
    Nisin, an amphiphilic, antimicrobial peptide, has been shown to integrate into the hydrophobic inner region of poly(ethylene oxide) (PEO) brush layers; however, the presence of integrated nisin may compromise the protein repulsive character of the PEO layer. In particular, the introduction of fibrinogen to nisin-loaded brush layers has been observed...
    Resource Type:
    Masters Thesis
    Full Text:
    A. Auxier, Justen K. Dill, Karl F. Schilke, Joseph McGuire * School of Chemical, Biological

  • Characterization and application of PEO-containing triblock copolymer surfactants

    Creator:
    Snider, Joshua L.
    Abstract:
    The action of pendant, polyethylene oxide (PEO) brush layers as nonfouling coatings for biomedical materials is well understood. However progress toward clinical application of stable, high density PEO coatings has historically been impeded by the lack of cost effective, noninvasive methods for their preparation. Triblock polymers featuring a hydrophobic, polypropylene...
    Resource Type:
    Honors College Thesis
    Full Text:
    . 4, pp. 859-864). ………….......... 21 Appendix B: Heintz, K., Schilke, K.F., Snider, J., Lee, W

  • Human platelet adhesion to heparinized silica surfaces

    Creator:
    Bolsinger, Travis Samuel Sebastian
    Abstract:
    Heparin was modified and immobilized to surface-activated silica surfaces using two different reaction schemes. End-aminated heparin was reacted with 2-iminothiolane to produce free thiol groups at the terminal ends of the heparin chains. The end-thiolated heparin was immobilized by reaction with a pyridyl disulfide activated poly[ethylene oxide]-poly[propylene oxide]-poly[ethylene oxide] triblock...
    Resource Type:
    Masters Thesis
    Full Text:
    measurements were performed using a K-alpha XPS instrument (Thermoscientific, UK). The x-ray source was from

  • Molecular origins of peptide entrapment in polyethylene oxide layers

    Creator:
    Wu, Xiangming
    Abstract:
    A more quantitative understanding of peptide entrapment and elution from otherwise protein-repellent polyethylene oxide (PEO) brush layers will provide direction for development of new strategies for drug storage and delivery. Here we describe criteria for peptide integration and structural change within the PEO brush, and discuss the reversibility of peptide...
    Resource Type:
    Dissertation

  • Binding of bacterial lipopolysaccharide by the cationic amphiphilic peptide WLBU2 at interfaces

    Creator:
    Ryder, Matthew P.
    Abstract:
    Passage of blood through a sorbent device for removal of bacteria and endotoxin by specific binding with immobilized, membrane-active, bactericidal peptides holds promise for treating severe blood infections. Peptide insertion in the target membrane and stable binding is desirable, while membrane disruption and release of degradation products to the circulating...
    Resource Type:
    Dissertation