Index Catalog // ScholarsArchive@OSU

Creator:: Wang, Jun, 1968-
Abstract:: Surface tension kinetics exhibited by selected stability mutants of T4 lysozyme at the air-water interface were monitored with DuNoüy tensiometry. Mutant lysozymes were produced by substitution of isoleucine at position 3 with cysteine, leucine, tryptophan and glycine. Each substitution resulted in an altered structural stability quantified by a change in...
Resource Type:: Masters Thesis
Full Text:: ribonuclease-A) at bulk concentrations of 0.01 mg/ml and 1.0 mg/ml using the Wilhelmy Plate method to

Creator:: Chu, Liping
Abstract:: The surface tension kin'ti4tnd ste'dy state behavior exhibited by mixtures of selected surfactants with a recombinant Factor VIII (rFVIII) were evaluated with automated interfacial tensiometry. In particular, fresh solutions of rFVIII with different concentrations of Tween 80, sodium dodecylsulfate (SDS), or dodecyltrimethylammonium bromide (DTAB) were prepared and their surface tension...
Resource Type:: Masters Thesis
Full Text:: ste'dy state behavior exhibited by mixtures of selected surfactants with a recombinant Factor VIII

Creator:: Podhipleux, Nilobon
Resource Type:: Dissertation
Full Text:: the Wild Type and a Synthetic Structural Stability Variant of Bacteriophage T4 Lysozyme. Abstract

Creator:: Gray, Warren D.
Abstract:: The primary goal was to characterize the adsorption of a recombinant therapeutic protein in the presence of selected surfactant species at the air-water interface. For this purpose, dynamic interfacial tensiometry was used to determine the surface tension kinetics exhibited by protein solutions containing either Tween 80 or the poly[ethylene oxide]-...
Resource Type:: Honors College Thesis
Full Text:: methods differed. The Wilhelmy Plate, the first probe to be tested, used a “discontinuous” sampling

Creator:: Alkhatib, Aveen K.
Abstract:: The adsorption behavior of a human recombinant Factor VIII (rFVIII) in the presence of the nonionic, poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) (PEO-PPO-PEO) triblock surfactant Pluronic® F-68 was evaluated by dynamic air-water tensiometry. Surface tension kinetics were recorded for F-68 in the absence of protein at concentrations ranging from 0 to 10,000...
Resource Type:: Masters Thesis
Full Text:: : _____________________________________________________________________ Joseph McGuire The adsorption behavior of a human recombinant Factor VIII (rFVIII) in the

Creator:: Joshi, Omkar
Abstract:: The role of the nonionic surfactant Tween 80 on the behavior of the therapeutic recombinant protein Factor VIII (rFVIII) was investigated at solid/liquid and air/water interfaces. In order to provide a model system to compare results obtained for the complicated rFVIII-Tween system, a well-characterized globular protein lysozyme was used. The...
Resource Type:: Dissertation
Full Text:: Factor VIII (rFVIII) was investigated at solid/liquid and air/water interfaces. In order to provide a

Creator:: Lee, Hyo Jin
Abstract:: Nonionic surfactants are commonly used to stabilize proteins during upstream and downstream processing and drug formulation. Surfactants stabilize the proteins through two major mechanisms: (i) their preferential location at nearby interfaces, in this way precluding protein adsorption; and/or (ii) their association with protein into "complexes" that prevent proteins from interacting...
Resource Type:: Dissertation
Full Text:: results were interpreted with reference to a mechanism for surfactant adsorption governed by the

ScholarsArchive@OSU