Index Catalog // ScholarsArchive@OSU

Molecular Origins of Recombinant Factor VIII (rFVIII)

Creator:: Tadehara, Katherine M.
Abstract:: The capability of Pluronic® F68 to stabilize human recombinant Factor VIII in solution was assessed using zeta potential measurements. Hemophilia A is a genetic disorder in which the body is missing Factor VIII (FVIII) from the blood coagulation cascade. The pharmaceutical industry developed recombinant Factor VIII (rFVIII), the largest cloned...
Resource Type:: Honors College Thesis
Full Text:: Katherine M. Tadehara A PROJECT Submitted to Oregon State University University

Synthesis and anticoagulant function of heparin containing block copolymers on polystyrene microspheres

Creator:: Fry, Allyson Kaye
Abstract:: Contact of blood with the surfaces of synthetic materials is associated with spontaneous protein adsorption, initiating platelet aggregation, the coagulation cascade, and the eventual development of a stable clot. Current therapy to inhibit implant-induced thrombosis is life-long administration of systemic anticoagulants. An alternative to the systemic administration of anticoagulant drugs...
Resource Type:: Masters Thesis
Full Text:: approved: _____________________________________________________________________ Joseph McGuire

The adsorption of human recombinant factor VIII in the presence of the nonionic triblock surfactant Pluronic® F-68 at the air-water interface

Creator:: Alkhatib, Aveen K.
Abstract:: The adsorption behavior of a human recombinant Factor VIII (rFVIII) in the presence of the nonionic, poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) (PEO-PPO-PEO) triblock surfactant Pluronic® F-68 was evaluated by dynamic air-water tensiometry. Surface tension kinetics were recorded for F-68 in the absence of protein at concentrations ranging from 0 to 10,000...
Resource Type:: Masters Thesis
Full Text:: : _____________________________________________________________________ Joseph McGuire The adsorption behavior of a human recombinant Factor VIII (rFVIII) in the

Synthesis and function of bioactive, block copolymer surfactant constructs as relevant to the preparation of anticoagulant and antibacterial medical implant surfaces.

Creator:: Joshi, Pranav R.
Abstract:: Nisin, an antibacterial peptide proven to be an effective inhibitor of Gram-positive bacteria, was incorporated into novel block copolymer constructs and tested for retained antibacterial activity. Covalent coupling was achieved by chemical modification of the N-terminal isoleucine to introduce a thiol group. Thiolated nisin derivatives were then linked to poly[ethylene...
Resource Type:: Dissertation
Full Text:: : _____________________________________________________________________ Joseph McGuire Nisin, an antibacterial peptide proven to be an effective inhibitor of Gram

The influence of surface functional groups on β-lactoglobulin adsorption equilibrium

Creator:: Al-Makhlafi, Hamood K.
Abstract:: Interactions between proteins and contact surfaces can have important implications in the food industry. Such interactions contribute to the course of fouling of membrane surfaces and they appear to mediate bacterial and spore adhesion to some degree as well. In addition to protein and solution properties, interfacial behavior is strongly...
Resource Type:: Masters Thesis
Full Text:: : . . „. . . / -JIM Dp Joseph McGuire Interactions between proteins and contact surfaces can have important

Nisin adsorption to PEO-PPO-PEO tri-block copolymer layers and its resistance to elution by fibrinogen

Creator:: Ryder, Matthew P.
Abstract:: While hydrophobic surfaces coated with the poly[ethylene oxide]-poly[propylene oxide]-poly[ethylene oxide] (PEO-PPO-PEO) surfactant Pluronic® F108 are highly resistant to plasma protein adsorption, the antimicrobial peptide nisin has been observed to adsorb in multilayer quantities at such surfaces, and the PEO chains themselves suggested to inhibit nisin exchange by blood proteins. But...
Resource Type:: Masters Thesis
Full Text:: approved: ________________________________________________________________________ Joseph McGuire

Surfactant Effects on Adsorption of Recombinant Factor VIII (rFVIII) at the Air-Water Interface

Creator:: Gray, Warren D.
Abstract:: The primary goal was to characterize the adsorption of a recombinant therapeutic protein in the presence of selected surfactant species at the air-water interface. For this purpose, dynamic interfacial tensiometry was used to determine the surface tension kinetics exhibited by protein solutions containing either Tween 80 or the poly[ethylene oxide]-...
Resource Type:: Honors College Thesis
Full Text:: -Water Interface. Abstract Approved: ______________________________________________________ Joseph

Structural effects on enzymatic activity of bacteriophage T4 lysozyme upon adsorption to colloidal silica

Creator:: Xu, Qiurong, 1964-
Resource Type:: Masters Thesis
Full Text:: would like to thank Dr. Joseph McGuire, my major professor, for his valuable guidance, encouragement

Characterization and application of PEO-containing triblock copolymer surfactants

Creator:: Snider, Joshua L.
Abstract:: The action of pendant, polyethylene oxide (PEO) brush layers as nonfouling coatings for biomedical materials is well understood. However progress toward clinical application of stable, high density PEO coatings has historically been impeded by the lack of cost effective, noninvasive methods for their preparation. Triblock polymers featuring a hydrophobic, polypropylene...
Resource Type:: Honors College Thesis
Full Text:: : ______________________________________________________________ Joseph McGuire The action of pendant, polyethylene oxide (PEO) brush layers as nonfouling

Use of contact angle analysis for the measurement of the relative hydrophilicity of food contact surfaces

Creator:: Kirtley, Sidney A.
Resource Type:: Masters Thesis
Full Text:: . Abstract approved: M cMjoseph McGuire A simple method for evaluation of food contact material

ScholarsArchive@OSU

Molecular Origins of Recombinant Factor VIII (rFVIII)

Synthesis and anticoagulant function of heparin containing block copolymers on polystyrene microspheres

The adsorption of human recombinant factor VIII in the presence of the nonionic triblock surfactant Pluronic® F-68 at the air-water interface

Synthesis and function of bioactive, block copolymer surfactant constructs as relevant to the preparation of anticoagulant and antibacterial medical implant surfaces.

The influence of surface functional groups on β-lactoglobulin adsorption equilibrium

Nisin adsorption to PEO-PPO-PEO tri-block copolymer layers and its resistance to elution by fibrinogen

Surfactant Effects on Adsorption of Recombinant Factor VIII (rFVIII) at the Air-Water Interface

Structural effects on enzymatic activity of bacteriophage T4 lysozyme upon adsorption to colloidal silica

Characterization and application of PEO-containing triblock copolymer surfactants

Use of contact angle analysis for the measurement of the relative hydrophilicity of food contact surfaces

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