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Filtering by: Creator Filichkin, Sergei A. Remove constraint Creator: Filichkin, Sergei A. Advisor Megraw, Molly Remove constraint Advisor: Megraw, Molly

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  • Validation of Predicted Functional Transcription Factor Binding Sites in Arabidopsis thaliana

    Creator:
    Ozguc, Olivia R.
    Abstract:
    Gene expression is largely regulated by the binding of transcription factors to short sequences of DNA (transcription factor binding sites) to drive or repress transcription of an adjacent gene. Identifying the key transcription factor binding sites associated with a particular biological outcome provides an avenue for tailored transcriptional regulation in...
    Resource Type:
    Honors College Thesis
    Full Text:
    was built using data generated by Maria Ivanchenko and Sergei Filichkin, with algorithms implemented

  • Investigating Transcriptional Control of Specialized Gene Expression in Plants

    Creator:
    Fraser, Valerie N.
    Abstract:
    Specialized or secondary metabolism is a collection of pathways and small molecules that, while beneficial to an organism, are not strictly necessary for survival. Plants use secondary metabolites to, among other things, attract pollinators, defend against biotic and abiotic stressors, and form symbioses. Natural products from plants have seen an...
    Resource Type:
    Dissertation
    Full Text:
    your kind mentorship throughout our collaborations. To Dr. Sergei Filichkin and to the late Dr. Maria

  • Computational Approaches for Understanding Combinatorial Gene Regulation

    Creator:
    Ansariola, Mitra
    Abstract:
    Gene regulation is a complex mechanism that controls the spatial and temporal expression of genes in a living cell. My dissertation studies focus on two problems. First, tissue-specific gene expression prediction from DNA sequence and chromatin state, and second, the accurate discovery of small over-represented regulatory circuits in gene regulatory...
    Resource Type:
    Dissertation
    Full Text:
    Dr. Je↵ Chang, Dr. Barbara Taylor, Dr. Sergei Filichkin, and Dr. Maria Ivanchenko. I also would

  • Prediction of gene transcription start sites and initiation patterns from DNA sequence content

    Creator:
    Morton, Taj H.
    Abstract:
    The computational identification of gene Transcription Start Sites (TSSs) can provide insights into the regulation and function of genes without performing expensive experiments, particularly in organisms with incomplete annotations. High-resolution general-purpose TSS prediction remains a challenging problem, with little recent progress on the identification and differentiation of TSSs which are...
    Resource Type:
    Masters Thesis
    Full Text:
    , Jason Cumbie, Sergei Filichkin, Maria Ivanchenko, and Spencer Kisler—for all their advice and