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Filtering by: Advisor Bond, F. Thomas Advisor Murray, Thomas F. Creator Berman, Frederick W.

Development and characterization of a model of glutamate and domoate toxicity in cultured rat cerebellar granule neurons

Creator:

Berman, Frederick W.

Abstract:

A model of acute glutamate- and domoate-induced toxicity was developed and characterized in cultured rat cerebellar granule cells (CGCs) using experimental conditions which preserve the voltage-dependency of NMDA receptor function. Glutamate, which is normally non-toxic to CGCs in physiologic media (pH 7.4), was shown to induce a cytotoxic response after...

Resource Type:

Dissertation

Full Text:

Granule Neurons. Abstract approved: Thomas F. Murray A model of acute glutamate- and domoate-induced