Although considerable experimental evidence suggests that
endogenous adenosine may function as a modulator of neuronal activity
in the etiology or control of seizures, the neuroanatomical and
neurochemical basis for the anticonvulsant actions of adenosine have
not been well established. A discrete brain region of possible
fundamental importance to epileptogenisis within...
Adenosine is considered to be a neuromodulator or
cotransmitter in the periphery and CNS. This neuromodulatory
action of adenosine may be observed as an anticonvulsant effect.
Dose-response curves for R-phenylisopropyladenosine (PIA),
cyclohexyladenosine (CHA), 2-chloroadenosine (2-ClAdo), Nethylcarboxamidoadenosine
(NECA) and S-PIA were generated against
PTZ seizure thresholds in the rat. The rank...