A model of acute glutamate- and domoate-induced toxicity was developed and characterized in cultured rat cerebellar granule cells (CGCs) using experimental conditions which preserve the voltage-dependency of NMDA receptor function. Glutamate, which is normally non-toxic to CGCs in physiologic media (pH 7.4), was shown to induce a cytotoxic response after...
The peripheral-type benzodiazepine receptor (PTBR) of trout brain was
pharmacologically characterized and pyrethroid interaction with this site
investigated. High-affinity binding sites for [³H]PK 11195 were detected in brain
membranes of rainbow trout; these shared some of the characteristics of the
PTBR of rodent brain (i.e., high affinity for PK 11195...
Cardiac A₁ adenosine receptors mediate cardioinhibitory
properties of adenosine and structural congeners. The objective of
these studies was to increase our understanding of molecular
processes involved in ligand interactions with receptors mediating
cardioinhibitory effects of adenosine and the interactions of these
receptors with guanine nucleotide binding regulatory proteins.
Porcine atrial...
Although considerable experimental evidence suggests that
endogenous adenosine may function as a modulator of neuronal activity
in the etiology or control of seizures, the neuroanatomical and
neurochemical basis for the anticonvulsant actions of adenosine have
not been well established. A discrete brain region of possible
fundamental importance to epileptogenisis within...