Index Catalog // ScholarsArchive@OSU

Creator:: Szot, Patricia
Abstract:: Adenosine is considered to be a neuromodulator or cotransmitter in the periphery and CNS. This neuromodulatory action of adenosine may be observed as an anticonvulsant effect. Dose-response curves for R-phenylisopropyladenosine (PIA), cyclohexyladenosine (CHA), 2-chloroadenosine (2-ClAdo), Nethylcarboxamidoadenosine (NECA) and S-PIA were generated against PTZ seizure thresholds in the rat. The rank...
Resource Type:: Dissertation
Full Text:: observed as an anticonvulsant effect. Dose-response curves for R-phenylisopropyladenosine (PIA

Creator:: Devaud, Leslie L.
Resource Type:: Dissertation
Full Text:: ]Ro5-4864 binding to rat olfactory bulb membranes: effect of cismethrin. 16. Schild plot of

Creator:: Zhang, Ge
Abstract:: Although considerable experimental evidence suggests that endogenous adenosine may function as a modulator of neuronal activity in the etiology or control of seizures, the neuroanatomical and neurochemical basis for the anticonvulsant actions of adenosine have not been well established. A discrete brain region of possible fundamental importance to epileptogenisis within...
Resource Type:: Masters Thesis
Full Text:: rank order potency, degree of stereoselectivity for R-PIA vs S-PIA and lack of anticonvulsant effect

Creator:: Leid, Mark
Abstract:: Cardiac A₁ adenosine receptors mediate cardioinhibitory properties of adenosine and structural congeners. The objective of these studies was to increase our understanding of molecular processes involved in ligand interactions with receptors mediating cardioinhibitory effects of adenosine and the interactions of these receptors with guanine nucleotide binding regulatory proteins. Porcine atrial...
Resource Type:: Dissertation
Full Text:: I -1 Physiological effects of adenosine in various tissues and cell types 18 CHAPTER II II -1

Creator:: Eshleman, Amy J.
Abstract:: The peripheral-type benzodiazepine receptor (PTBR) of trout brain was pharmacologically characterized and pyrethroid interaction with this site investigated. High-affinity binding sites for [³H]PK 11195 were detected in brain membranes of rainbow trout; these shared some of the characteristics of the PTBR of rodent brain (i.e., high affinity for PK 11195...
Resource Type:: Dissertation
Full Text:: effect a GABA- dependent inhibition of [35S]TBPS binding. Ro5-4864, which showed micromolar affinity

Creator:: Zhang, Ge, 1956-
Resource Type:: Dissertation
Full Text:: ; and the anticonvulsant effect of NECA was completely abolished by the adenosine receptor antagonist 8

Creator:: Zhao, Xiaoqin S.
Resource Type:: Masters Thesis
Full Text:: anticonvulsant effect of 2 methylthio-ATP is therefore likely to be due to its breakdown to 2-methylthio

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