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The Effects of Rapamycin on the Unfolded Protein Response in Relation to Healthy Aging

Creator:

Zhao, Stephanie Anne

Abstract:

The loss of proteostasis is the mechanism for maintaining properly folded proteins and degrading misfolded ones. One protective mechanism against loss of proteostasis is the Unfolded Protein Response (UPR), a chaperone mediated folding system in the Endoplasmic Reticulum (ER). The UPR communicates with the Nrf2 pathway, a transcription factor, and...

Resource Type:

Honors College Thesis

Full Text:

my questions. I would also like to acknowledge Natalia Diaz, who, in her short time in the lab
Comparing 26S Proteasome Efficiency Between Long-Living and Short-Living Rodents

Creator:

Bradley, Lynda M.

Abstract:

Many people die yearly worldwide due to diseases associated with aging, and if the process of aging in humans was more understood, the health of these patients could be improved. While many biochemical actions are involved with the aging process, loss of proteostasis has been called one of the most...

Resource Type:

Honors College Thesis

Full Text:

(Dantuma et al., 2000; Santiago-Josefat, Pozo-Guisado, Mulero-Navarro, & Fernandez- Salguero, 2001). As