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Filtering by: Creator Dumas, Philip Conrad Advisor Proteau, Philip J.

Syntheses and evaluation of putative enzyme inhibitor of isoprenoid biosynthesis

Creator:

Phaosiri, Chanokporn

Abstract:

The discovery of the methylerythritol phosphate pathway (the MEP pathway) as an alternate pathway for isoprenoid biosynthesis in some organisms including most bacteria, malarial parasites and plants, but not in animals, has stimulated extensive studies in this area. Research has revealed the potential of finding novel antibacterials, antimalarial drugs, and...

Resource Type:

Dissertation

Full Text:

of Putative Enzyme Inhibitors of Isoprenoid Biosynthesis Abstract approved: Philip The discovery
Studies of non-mevalonate isoprenoid biosynthesis : the 1-deoxy-D-xylulose-5-phosphate isomeroreductase (DXR) mediated reaction

Creator:

Woo, Youn-Hi

Abstract:

This dissertation details the investigation of an alternate pathway to isoprenoids that occurs in plants and microorganisms, the non-mevalonate pathway. This exploration of the pathway focuses on the second step, the conversion of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methylerythritol-4-phosphate (MEP) by the enzyme DXP isomeroreductase (DXR). These studies led to an appreciation...

Resource Type:

Dissertation
Studies on 1-deoxy-D-xylulose 5-phosphate reductoisomerase from Synechocystis sp. PCC6803 : characterization of mutants and inhibitors

Creator:

Fernandes, Roberta P. M.

Abstract:

In recent years, the methyl erythritol phosphate (MEP) pathway to isoprenoids has been the subject of intensive research. The interest is because isoprenoids have important roles in many cellular processes essential for the survival of several pathogenic organisms, making the inhibition of this pathway an attractive target for the drug...

Resource Type:

Dissertation