Recent studies have demonstrated that perturbations of
intracellular thiol and calcium homeostasis may be important events
in the early development of cell injury by toxic chemicals.
Incubation of isolated rat hepatocytes in a calcium free
medium, severely depleted intracellular Ca²⁺ levels and resulted in
the loss of both cytosolic and...
Lipid peroxidation is believed to be an important
process in the development of cellular injury. In
addition to the degradation of biological membranes,
increasing evidence indicates that lipid peroxidation can
alter the structure and function of DMA.
The present study examines the peroxidation of
nuclear membranes and the capacity of...