Index Catalog // ScholarsArchive@OSU

Status of mitochondrial glutathione and energy levels during cyclosporin A-sensitive permeability transition induced by calcium and inorganic phosphate

Creator:: Savage, Melani K.
Resource Type:: Dissertation
Full Text:: . Reed, Ph.D. The status of glutathione was studied in isolated rat liver mitochondria during

Glutathione conjugation as a determinant in 1,2-dihaloethane and alpha-naphthylisothiocyanate toxicity

Creator:: Jean, Paul A.
Resource Type:: Dissertation
Full Text:: . Abstract approved: Redacted for Privacy Ddnald J. Reed, Ph.D. Glutathione, a ubiquitous cellular

Effects of washing and aging on the metabolism of red beet root slices

Creator:: Kolattukudy, Pappachan Ettoop
Abstract:: The rate of the C¹⁴0₂ release from glucose, specifically labeled with C¹⁴ at 1, 2, 3+4, and positions, was used to study the relative participation of pathways of glucose catabolism in red beet slices. Evidence was obtained which indicated that in mature red beets glucose was catabolized mainly via glycolysis-tricarboxylic...
Resource Type:: Dissertation
Full Text:: thank Dr. D. J. Reed for his liberal guidance throughout the course of this work, The assistance of

Analysis of cytochrome P-450 isozymes from rat liver and studies on the mechanism of induction

Creator:: Williams, David Edward
Abstract:: In order to determine the total number of cytochrome P-450 isozymes present in a given species following various treatments, mature male rats (Sprague-Dawley) were injected intraperitoneally with the classic mixed-function oxidase inducers phenobarbital (PB), pregnenolone- 16a-carbonitrile (PCN), 3-methylcholanthrene (3-MC), or the appropriate control vehicle. Hepatic microsomes were solubilized and P-450...
Resource Type:: Masters Thesis
Full Text:: Abstract approved: Dr. Donald J. Reed In order to determine the total number of cytochrome P-450 iso

Studies on the inhibition of bovine plasma amine oxidase by hydrazines

Creator:: Hucko-Haas, Jacqueline Elizabeth
Abstract:: Several aspects of the potent inhibition of bovine plasma amine oxidase (PAO) by hydrazines were investigated by kinetic and preparative means. The inhibition was classified as pseudo-irreversible by the method of Ackerman and Potter (Proc. Soc. Exptl. Biol. Med. 72, 1 (1949), and was found to exhibit Zone B kinetic...
Resource Type:: Dissertation
Full Text:: Privacy Dr. Donald J. Reed Several aspects of the potent inhibition of bovine plasma amine oxidase (PAO

Mitochondrial glutathione and the effect of perturbed calcium homeostasis on rat hepatocyte thiols

Creator:: Olafsdottir, Kristin
Abstract:: Recent studies have demonstrated that perturbations of intracellular thiol and calcium homeostasis may be important events in the early development of cell injury by toxic chemicals. Incubation of isolated rat hepatocytes in a calcium free medium, severely depleted intracellular Ca²⁺ levels and resulted in the loss of both cytosolic and...
Resource Type:: Dissertation
Full Text:: . (1972) Fed. Proc. 31, 432-442. 4. Reed, P. W., and Lardy, H. A. (1972) in: Role of Membranes in

Some aspects of an oxidative tryptophan decarboxylating enzyme in Pisum sativum

Creator:: Taylor, Frank Farnham
Abstract:: Three types of experiments were designed to further characterize the tryptophan decarboxylating enzyme of Reed and Crecelius (1967). 1) Light inhibition studies were made with etiolated pea seedlings to determine the in vitro response of the tryptophan decarboxylating enzyme. Assays of indoleacetic acid oxidase (IAA oxidase) and guaiacol-active pea seedling...
Resource Type:: Masters Thesis
Full Text:: `Donald J. Reed Three types of experiments were designed to further charac- terize the tryptophan

Metabolic pathway of the nitrosoureas catalyzed by cytochrome P-450 and NADPH cytochrome P-450 reductase

Creator:: Potter, David Willard
Abstract:: Three highly purified forms of cytochrome P-450 (P-450a, P-450b, P-450c) from Aroclor 1254-induced rat hepatic microsomes catalyzed the monooxygenation of 1-(2- chloroethyl)-3-(trans-4-methylcyclohexyl)-1-nitrosourea (MeCCNU) and 1-(2-chloroethyl)-3-(cyclohexyl)-1-nitrosourea (CCNU) in the presence of purified NADPH cytochrome P-450 reductase, NADPH and oxygen. Cytochrome P -450- dependent monooxygenation of CCNU gave six alicyclic hydroxylation products...
Resource Type:: Dissertation
Full Text:: P-450 REDUCTASE Abstract approved: Redacted for privacy D. J. Reed Three highly purified forms

The conversion of some monoalkylhydrazines to their corresponding hydrocarbons by a hepatic microsomal enzyme system in rat

Creator:: Prough, Russell A.
Abstract:: An aspect of the metabolism of monoalkylhydrazines has been investigated using both intact rats and rat liver microsomal enzyme preparations. Intact rats respired propane and n-butane on administration of 0.3-0.5 mmoles of isopropyl- and n-butylhydrazine, respectively. Based upon dose administered, a five to ten percent yield of hydrocarbon was obtained....
Resource Type:: Dissertation
Full Text:: A HEPATIC MICROSOMAL ENZYME SYSTEM IN RAT Redacted for Privacy Abstract approved: Donald Reed An

Intracellular oxidation of glutathione in L-5178Y lymphoma cells by procarbazine and diamide : parallel studies

Creator:: Bump, Edward Allen
Resource Type:: Dissertation
Full Text:: Redacted for Privacy Abstract approved: Donald J. Reed A moderate but prolonged increase in the

ScholarsArchive@OSU

Status of mitochondrial glutathione and energy levels during cyclosporin A-sensitive permeability transition induced by calcium and inorganic phosphate

Glutathione conjugation as a determinant in 1,2-dihaloethane and alpha-naphthylisothiocyanate toxicity

Effects of washing and aging on the metabolism of red beet root slices

Analysis of cytochrome P-450 isozymes from rat liver and studies on the mechanism of induction

Studies on the inhibition of bovine plasma amine oxidase by hydrazines

Mitochondrial glutathione and the effect of perturbed calcium homeostasis on rat hepatocyte thiols

Some aspects of an oxidative tryptophan decarboxylating enzyme in Pisum sativum

Metabolic pathway of the nitrosoureas catalyzed by cytochrome P-450 and NADPH cytochrome P-450 reductase

The conversion of some monoalkylhydrazines to their corresponding hydrocarbons by a hepatic microsomal enzyme system in rat

Intracellular oxidation of glutathione in L-5178Y lymphoma cells by procarbazine and diamide : parallel studies

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