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Filtering by: Advisor Schilke, Karl F. Degree Field Bioengineering Degree Name Honors Bachelor of Science (H.B.S.) Peer Reviewed No

Structural and activity characterization of irradiated antimicrobial peptide (WLBU2) for use in blood processing and biomedical applications

Creator:

Cheung, Daniel Y. C.

Abstract:

Sepsis is a life-threatening blood infection which leads to an uncontrolled systemic inflammatory state. In North America alone, sepsis annually afflicts approximately 750,000 individuals and kills 38-50% of these (more than HIV/AIDS, breast cancer, and colon cancer combined). Current treatment involves administration of IV fluids, antibiotics and hemoperfusion, requiring prolonged...

Resource Type:

Honors College Thesis
Effect of Polyethylene Oxide (PEO) Modification on the Structure and Antimicrobial Activity of the Antimicrobial Peptide WLBU2

Creator:

Raper, Miranda A.

Abstract:

Sepsis is a blood infection that is caused by circulating bacteria cells and cell fragments, which contain immunogenic lipopolysaccharides (LPS) or endotoxin. The circulating endotoxin results in a severe dysregulation of the inflammatory response that ultimately leads to organ failure. One promising treatment method is removal of endotoxin by passing...

Resource Type:

Honors College Thesis
Developing a membrane leakage assay for the binding of bacterial lipopolysaccharide by the cationic amphiphilic peptide WLBU2

Creator:

Amsberry, Anthony C.

Abstract:

Sepsis, caused by bacterial release of endotoxin, is a serious blood infection that causes uncontrolled systemic immune response. In North America alone, sepsis kills between 220,000 and 380,000 people each year, more than prostate cancer, breast cancer, and HIV/AIDS combined. Sepsis treatment is complicated and often requires prolonged hospital stays,...

Resource Type:

Honors College Thesis

ScholarsArchive@OSU

Structural and activity characterization of irradiated antimicrobial peptide (WLBU2) for use in blood processing and biomedical applications

Effect of Polyethylene Oxide (PEO) Modification on the Structure and Antimicrobial Activity of the Antimicrobial Peptide WLBU2

Developing a membrane leakage assay for the binding of bacterial lipopolysaccharide by the cationic amphiphilic peptide WLBU2

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