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Filtering by: Advisor Schimerlik, Michael I. Date issued sim 2007-09-18

Alkylation kinetics of the human retinoid X receptor α using cysteine as a local probe

Creator:

Vanegas, Juan Manuel

Abstract:

The unfolding of human retinoid X receptor α in the presence of the denaturant guanidine HCl was studied using stopped-flow absorbance spectroscopy. The protein's four native cysteine residues were mutated to obtain four single-cysteine mutants, each with the other three cysteine residues mutated to alanine. The thiols of these hRXRα...

Resource Type:

Masters Thesis