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Filtering by: Creator dos Santos, Miguel N. Remove constraint Creator: dos Santos, Miguel N. Advisor Schuster, Martin Remove constraint Advisor: Schuster, Martin

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  • Social Evolution and Regulatory Architecture of Pseudomonas aeruginosa Quorum Sensing

    Creator:
    Asfahl, Kyle L.
    Abstract:
    Cell-cell communication in bacteria is understood to facilitate the coordination of population-wide cooperative behavior in the form of concerted gene expression. The opportunistic pathogen Pseudomonas aeruginosa uses such a communication mechanism to regulate a large group of genes important to virulence strategies in this bacterium. This general mechanism of communication...
    Resource Type:
    Dissertation
    Full Text:
    . aeruginosa, like many Gram-negative Proteobacteria, is mediated through the synthesis of diffusible N-acyl

  • Quorum-sensing-controlled public goods in Pseudomonas aeruginosa : regulation and application

    Creator:
    Mellbye, Brett L.
    Abstract:
    Cell-to-cell communication by chemical signals, termed quorum sensing (QS), is a common regulatory scheme in the microbial world. Pseudomonas aeruginosa¸ an opportunistic pathogen of burn wounds and cystic fibrosis lungs, uses QS to control the expression of hundreds of genes, particularly those necessary for population level benefits such as biofilm...
    Resource Type:
    Dissertation
    Full Text:
    . aeruginosa QS is considered a cooperative behavior that can be exploited by lasR mutant cheaters that do

  • The Fitness Costs and Regulatory Strategies of Cooperative Siderophore Production in Pseudomonas

    Creator:
    Sexton, David
    Abstract:
    Cooperative behaviors in bacteria are increasingly appreciated for their relevance to microbial ecology and utility as model systems for social evolution. One example is the secretion of siderophores, a structurally diverse group of compounds that chelate extracellular iron. Siderophore production is considered cooperative because the benefits can be shared with...
    Resource Type:
    Dissertation
    Full Text:
    siderophores they do not produce, indicating that social conflict is ecologically relevant. However, many

  • The Social Interactions of Pseudomonas aeruginosa

    Creator:
    Smith, Parker
    Abstract:
    Pseudomonas aeruginosa is a ubiquitous environmental microbe, opportunistic pathogen, and a highly social organism. P. aeruginosa utilizes a wide array of cooperative behaviors to adapt to the environmental conditions around it. These behaviors include quorum sensing (QS), a form a cell-to-cell signaling that coordinates the expression of secreted products in...
    Resource Type:
    Dissertation
    Full Text:
    thank Dr. Malcolm Lowry, Dr. Siva Kolluri, and Dr. Allison Ehrlich for training me how to do flow