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Filtering by: Creator van Kooten, G. Cornelis Remove constraint Creator: van Kooten, G. Cornelis Advisor Schuster, Martin Remove constraint Advisor: Schuster, Martin

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  • The Social Interactions of Pseudomonas aeruginosa

    Creator:
    Smith, Parker
    Abstract:
    Pseudomonas aeruginosa is a ubiquitous environmental microbe, opportunistic pathogen, and a highly social organism. P. aeruginosa utilizes a wide array of cooperative behaviors to adapt to the environmental conditions around it. These behaviors include quorum sensing (QS), a form a cell-to-cell signaling that coordinates the expression of secreted products in...
    Resource Type:
    Dissertation
    Full Text:
    proportion of cheaters is high (right). (G) Non-social adaptation. Mutations in cooperator cells allow

  • Social Evolution and Regulatory Architecture of Pseudomonas aeruginosa Quorum Sensing

    Creator:
    Asfahl, Kyle L.
    Abstract:
    Cell-cell communication in bacteria is understood to facilitate the coordination of population-wide cooperative behavior in the form of concerted gene expression. The opportunistic pathogen Pseudomonas aeruginosa uses such a communication mechanism to regulate a large group of genes important to virulence strategies in this bacterium. This general mechanism of communication...
    Resource Type:
    Dissertation
    Full Text:
    (Davies, et al., 1998), and virulence factor production (Van Delden & Iglewski, 1998). Many of these QS

  • The Fitness Costs and Regulatory Strategies of Cooperative Siderophore Production in Pseudomonas

    Creator:
    Sexton, David
    Abstract:
    Cooperative behaviors in bacteria are increasingly appreciated for their relevance to microbial ecology and utility as model systems for social evolution. One example is the secretion of siderophores, a structurally diverse group of compounds that chelate extracellular iron. Siderophore production is considered cooperative because the benefits can be shared with...
    Resource Type:
    Dissertation
    Full Text:
    , creating regulatory hierarchies that further refine the response to iron limitation (Cornelis et al

  • Quorum-sensing-controlled public goods in Pseudomonas aeruginosa : regulation and application

    Creator:
    Mellbye, Brett L.
    Abstract:
    Cell-to-cell communication by chemical signals, termed quorum sensing (QS), is a common regulatory scheme in the microbial world. Pseudomonas aeruginosa¸ an opportunistic pathogen of burn wounds and cystic fibrosis lungs, uses QS to control the expression of hundreds of genes, particularly those necessary for population level benefits such as biofilm...
    Resource Type:
    Dissertation
    Full Text:
    expressed even in the absence of a functional las system (van Delden et al., 1998, Diggle et al., 2003

  • Quorum sensing gene regulation in Pseudomonas aeruginosa

    Creator:
    Gupta, Rashmi
    Abstract:
    Pseudomonas aeruginosa is an opportunistic human pathogen that infects immunocompromised individuals such as those suffering from burns or the genetic disorder cystic fibrosis. This organism utilizes a cell-cell communication mechanism known as quorum sensing (QS) to coordinate virulence gene expression and biofilm formation. It has three interconnected QS systems, namely...
    Resource Type:
    Dissertation

  • Cooperation and conflict in Pseudomonas aeruginosa quorum sensing

    Creator:
    Wilder, Cara N.
    Abstract:
    Pseudomonas aeruginosa is an environmental bacterium as well as an opportunistic pathogen that primarily infects immunocompromised individuals, including those suffering from cystic fibrosis. The density-dependent regulation of gene expression via cell-to-cell communication, also termed quorum sensing (QS), is an important virulence determinant in this organism. Generally, P. aeruginosa uses three...
    Resource Type:
    Dissertation
    Full Text:
    al. 2003a, Van Delden et al. 1998). In addition to LasR and RhlR, there is a third, orphan