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Filtering by: Creator Bailey, Robert Remove constraint Creator: Bailey, Robert Advisor Tanguay, Robert L. Remove constraint Advisor: Tanguay, Robert L.

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  • Developmental ramifications of dithiocarbamate pesticide exposure in zebrafish

    Creator:
    Tilton, Fred Anthony, 1973-
    Abstract:
    Dithiocarbamates are widely used agricultural pesticides, industrial chemicals and effluent additives. DTCs and their related compounds have historical and current relevance in clinical and experimental medicine. DTC developmental toxicity is well established, but poorly understood. Dithiocarbamates according to the U.S. EPA have a mechanism of action involving, "the inhibition of...
    Resource Type:
    Dissertation
    Full Text:
    researcher, Bailey Laboratory) and Robert L. Tanguay on many of the staple methods of the Tanguay Laboratory

  • Classifying Chemical Bioactivity by Coupling High-throughput Phenotypic Anchoring and Transcriptome Profiling in Zebrafish

    Creator:
    Haggard, Derik
    Abstract:
    There are more than 87,000 chemicals in current use with little to no toxicity information available. Assessing such a large number of chemicals using traditional methods would take an unreasonable amount of time and money, and require the use a large number of animals. The incorporation of high-throughput in vivo...
    Resource Type:
    Dissertation
    Full Text:
    : ______________________________________________________________ Robert L. Tanguay There are more than 87,000 chemicals in current use with little to no

  • Defining PAH and Oxygen-substituted PAH-dependent Developmental and Adult Toxicity in Zebrafish

    Creator:
    Knecht, Andrea L.
    Abstract:
    Polycyclic aromatic hydrocarbons (PAHs) and oxygen-substituted PAHs (OPAHs) are environmental contaminants present in urban air, dust, soil and water resulting from incomplete combustion of organic materials or fossil fuels; found in crude oil and coal; and formed through photoxidation or biotransformation of microbial. It is widely recognized that PAHs pose...
    Resource Type:
    Dissertation
    Full Text:
    : ______________________________________________________________ Robert L. Tanguay Polycyclic aromatic hydrocarbons (PAHs) and oxygen-substituted PAHs (OPAHs

  • Developing rapid in vivo assays to investigate structure response relationships

    Creator:
    Truong, Lisa
    Abstract:
    Incorporation of nanoparticles (NPs) into consumer products is on the rise and human exposure to NPs is unavoidable. Currently, there is insufficient data to assess the safety of nanoparticles. I conducted a series of five studies using the zebrafish model to determine which NP components (i.e., core material or surface...
    Resource Type:
    Dissertation
    Full Text:
    : ______________________________________________________________ Robert L. Tanguay Incorporation of nanoparticles (NPs) into consumer products is on the rise

  • Utilization of the Zebrafish Model for Investigating Nitrated Polycyclic Aromatic Hydrocarbon Developmental Toxicity

    Creator:
    Chlebowski, Anna C.
    Abstract:
    Polycyclic aromatic hydrocarbons (PAHs) are among the most widely known and studied environmental contaminants, originating from a range of natural and anthropogenic sources. PAHs are known to occur in the environment as complex mixtures, containing both unsubstituted PAHs, as well as a range of PAH derivatives. Among the less-studied of...
    Resource Type:
    Dissertation
    Full Text:
    : _________________________________________________________________ Staci L. Massey Simonich Robert L. Tanguay