Index Catalog // ScholarsArchive@OSU

Classifying polycyclic aromatic hydrocarbon bioactivities using phenotypic screening and transcriptomics in the developmental zebrafish model

Creator:: Geier, Mitra Celestine
Abstract:: Polycyclic aromatic hydrocarbons (PAHs) are widespread environmental contaminants that occur in complex mixtures. These environmental mixtures can consist of both parent PAHs and their derivatives. Several parent PAHs are known or suspected mutagens and/or carcinogens, and a handful of PAH derivatives are known to be more potent mutagens and/or carcinogens...
Resource Type:: Dissertation
Full Text:: and advice on navigating graduate school, Dr. Sean Bugel for his enthusiasm, encouragement and

Vitamin E and the alpha-tocopherol transfer protein during zebrafish embryogenesis

Creator:: Miller, Galen W.
Abstract:: Vitamin E was first described in 1922 as an unknown factor required for impregnated rats to carry their offspring to term. In fact, when vitamin E was chemically characterized it was given the name "tocopherol" derived from the Greek: tokos = childbirth; phero = to bear; and –ol, indicating an...
Resource Type:: Dissertation
Full Text:: Goodale, Joe Fisher, Dr. Kitae Kim, Dr. Siba Das, Dr. Sean Bugel, Eric Johnson, David Mandrell, Chapell

Nanotoxicology to Nanotherapeutics : Prioritizing Hazard and Anticancer Efficacy of Nanomaterials using the Embryonic Zebrafish Model

Creator:: Wehmas, Leah C.
Abstract:: The numerous different types of nanomaterials and paucity of reliable in vivo information on toxicity has resulted in enduring uncertainties associated with health and safety risks, thereby slowing progress in nanotherapeutic assessment and development. This dissertation explores how the embryonic zebrafish model can be applied to prioritize commonly used nanomaterial...
Resource Type:: Dissertation
Full Text:: . A special thanks goes to Dr. Tod Harper Jr., Dr. Josephine Bonventre, Dr. Sean Bugel and Jane Ladu

Developmental toxicity of polycyclic aromatic hydrocarbons : defining mechanisms with systems-based transcriptional profiling

Creator:: Goodale, Britton C.
Abstract:: Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous in the environment as components of fossil fuels and by-products of combustion. Defining toxicity mechanisms for this large family of multi-ring structures and substituted derivatives is a substantial challenge. Several PAHs, such as benzo(a)pyrene (BaP), are mutagenic, toxic to wildlife, and classified as probable...
Resource Type:: Dissertation
Full Text:: company in the lab; Sean Bugel for sharing the office with the window and the challenge assay, providing

Transcriptomic approaches for discovering regenerative and developmental regulatory networks in zebrafish

Creator:: Garland, Michael A.
Abstract:: Zebrafish are capable of fully regenerating organs and tissue such as their caudal fin, which is similar to a human regrowing an arm or a leg. In contrast, most mammals including humans have a greatly reduced capacity for wound healing. The ability of zebrafish to undergo this regenerative process, called...
Resource Type:: Dissertation
Full Text:: would also like to thank Dr. Sean Bugel and Dr. Josie Bonventre, whose friendship and adventures

Defining PAH and Oxygen-substituted PAH-dependent Developmental and Adult Toxicity in Zebrafish

Creator:: Knecht, Andrea L.
Abstract:: Polycyclic aromatic hydrocarbons (PAHs) and oxygen-substituted PAHs (OPAHs) are environmental contaminants present in urban air, dust, soil and water resulting from incomplete combustion of organic materials or fossil fuels; found in crude oil and coal; and formed through photoxidation or biotransformation of microbial. It is widely recognized that PAHs pose...
Resource Type:: Dissertation
Full Text:: them for their support and friendship. I want to thank Leah Wehmas, Josie Bonventre, Sean Bugel

Classifying Chemical Bioactivity by Coupling High-throughput Phenotypic Anchoring and Transcriptome Profiling in Zebrafish

Creator:: Haggard, Derik
Abstract:: There are more than 87,000 chemicals in current use with little to no toxicity information available. Assessing such a large number of chemicals using traditional methods would take an unreasonable amount of time and money, and require the use a large number of animals. The incorporation of high-throughput in vivo...
Resource Type:: Dissertation
Full Text:: , Leah Wehmas, Yasmeen Nkrumah-Elie, and Sean Bugel for being the original members of the lab when I

Utilization of the Zebrafish Model for Investigating Nitrated Polycyclic Aromatic Hydrocarbon Developmental Toxicity

Creator:: Chlebowski, Anna C.
Abstract:: Polycyclic aromatic hydrocarbons (PAHs) are among the most widely known and studied environmental contaminants, originating from a range of natural and anthropogenic sources. PAHs are known to occur in the environment as complex mixtures, containing both unsubstituted PAHs, as well as a range of PAH derivatives. Among the less-studied of...
Resource Type:: Dissertation
Full Text:: life, during my graduate studies: Dr. Cleo Davie-Martin, Dr. Courtney Roper, Dr. Sean Bugel, Dr. Leah

Developmental neurobehavioral toxicity of bisphenol A in zebrafish (Danio rerio)

Creator:: Saili, Katerine Schletz
Abstract:: Billions of pounds of bisphenol A (BPA) are produced annually around the globe for the manufacture of numerous consumer products, including polycarbonate food and water containers, the protective resin linings of food cans, thermal printing paper, and dental fillings. BPA exposure during nervous system development has been associated with learning...
Resource Type:: Dissertation
Full Text:: produce the inactive metabolite, BPA-4-β-D-glucuronide (Pottenger et al. 2000; Snyder et al. 2000

Developing rapid in vivo assays to investigate structure response relationships

Creator:: Truong, Lisa
Abstract:: Incorporation of nanoparticles (NPs) into consumer products is on the rise and human exposure to NPs is unavoidable. Currently, there is insufficient data to assess the safety of nanoparticles. I conducted a series of five studies using the zebrafish model to determine which NP components (i.e., core material or surface...
Resource Type:: Dissertation
Full Text:: expertise: Dr. Sean Bugel, Dr. Siba Das, Joe Fisher, Jill Franzosa, Britton Goodale, Derik Haggard, Dr

ScholarsArchive@OSU

Classifying polycyclic aromatic hydrocarbon bioactivities using phenotypic screening and transcriptomics in the developmental zebrafish model

Vitamin E and the alpha-tocopherol transfer protein during zebrafish embryogenesis

Nanotoxicology to Nanotherapeutics : Prioritizing Hazard and Anticancer Efficacy of Nanomaterials using the Embryonic Zebrafish Model

Developmental toxicity of polycyclic aromatic hydrocarbons : defining mechanisms with systems-based transcriptional profiling

Transcriptomic approaches for discovering regenerative and developmental regulatory networks in zebrafish

Defining PAH and Oxygen-substituted PAH-dependent Developmental and Adult Toxicity in Zebrafish

Classifying Chemical Bioactivity by Coupling High-throughput Phenotypic Anchoring and Transcriptome Profiling in Zebrafish

Utilization of the Zebrafish Model for Investigating Nitrated Polycyclic Aromatic Hydrocarbon Developmental Toxicity

Developmental neurobehavioral toxicity of bisphenol A in zebrafish (Danio rerio)

Developing rapid in vivo assays to investigate structure response relationships

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