Index Catalog // ScholarsArchive@OSU

Developmental neurobehavioral toxicity of bisphenol A in zebrafish (Danio rerio)

Creator:: Saili, Katerine Schletz
Abstract:: Billions of pounds of bisphenol A (BPA) are produced annually around the globe for the manufacture of numerous consumer products, including polycarbonate food and water containers, the protective resin linings of food cans, thermal printing paper, and dental fillings. BPA exposure during nervous system development has been associated with learning...
Resource Type:: Dissertation
Full Text:: mentorship. I am grateful to have shared several years in the lab with Jill Franzosa, Dr. Sumitra Sengupta

Transcriptomic approaches for discovering regenerative and developmental regulatory networks in zebrafish

Creator:: Garland, Michael A.
Abstract:: Zebrafish are capable of fully regenerating organs and tissue such as their caudal fin, which is similar to a human regrowing an arm or a leg. In contrast, most mammals including humans have a greatly reduced capacity for wound healing. The ability of zebrafish to undergo this regenerative process, called...
Resource Type:: Dissertation
Full Text:: particular, due credit must go to Dr. Jill Franzosa, Dr. Mitra Geier, and Dr. Sumitra Sengupta for their

Vitamin E and the alpha-tocopherol transfer protein during zebrafish embryogenesis

Creator:: Miller, Galen W.
Abstract:: Vitamin E was first described in 1922 as an unknown factor required for impregnated rats to carry their offspring to term. In fact, when vitamin E was chemically characterized it was given the name "tocopherol" derived from the Greek: tokos = childbirth; phero = to bear; and –ol, indicating an...
Resource Type:: Dissertation
Full Text:: the Tanguay lab as well for all of their support and expertise: Jill Franzosa, Kate Saili, Britton

Chemical and biological approaches to identify vertebrate tissue regeneration pathways

Creator:: Sengupta, Sumitra
Abstract:: Numerous human conditions would be improved if therapies to encourage tissue regeneration were available. The goal of regenerative medicine is to encourage the body's intrinsic ability to repair and restore tissues lost by disease, injury or aging. While certain vertebrates have the inherent capacity to regenerate, mammals do not. To...
Resource Type:: Dissertation
Full Text:: manuscript. Jill A Franzosa helped with the retinoic acid exposure experiments. In Chapter 2, Dr. Lijoy K

Classifying Chemical Bioactivity by Coupling High-throughput Phenotypic Anchoring and Transcriptome Profiling in Zebrafish

Creator:: Haggard, Derik
Abstract:: There are more than 87,000 chemicals in current use with little to no toxicity information available. Assessing such a large number of chemicals using traditional methods would take an unreasonable amount of time and money, and require the use a large number of animals. The incorporation of high-throughput in vivo...
Resource Type:: Dissertation
Full Text:: toxicity information available. Assessing such a large number of chemicals using traditional methods

Developmental toxicity of polycyclic aromatic hydrocarbons : defining mechanisms with systems-based transcriptional profiling

Creator:: Goodale, Britton C.
Abstract:: Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous in the environment as components of fossil fuels and by-products of combustion. Defining toxicity mechanisms for this large family of multi-ring structures and substituted derivatives is a substantial challenge. Several PAHs, such as benzo(a)pyrene (BaP), are mutagenic, toxic to wildlife, and classified as probable...
Resource Type:: Dissertation
Full Text:: thoughtful answers to my many questions, and for the excellent discussions; Jill Franzosa for encouragement

Developing rapid in vivo assays to investigate structure response relationships

Creator:: Truong, Lisa
Abstract:: Incorporation of nanoparticles (NPs) into consumer products is on the rise and human exposure to NPs is unavoidable. Currently, there is insufficient data to assess the safety of nanoparticles. I conducted a series of five studies using the zebrafish model to determine which NP components (i.e., core material or surface...
Resource Type:: Dissertation
Full Text:: expertise: Dr. Sean Bugel, Dr. Siba Das, Joe Fisher, Jill Franzosa, Britton Goodale, Derik Haggard, Dr

Defining PAH and Oxygen-substituted PAH-dependent Developmental and Adult Toxicity in Zebrafish

Creator:: Knecht, Andrea L.
Abstract:: Polycyclic aromatic hydrocarbons (PAHs) and oxygen-substituted PAHs (OPAHs) are environmental contaminants present in urban air, dust, soil and water resulting from incomplete combustion of organic materials or fossil fuels; found in crude oil and coal; and formed through photoxidation or biotransformation of microbial. It is widely recognized that PAHs pose...
Resource Type:: Dissertation
Full Text:: embryonic zebrafish model. In our first study, we conducted a comprehensive toxicity screen of 38

Utilization of the Zebrafish Model for Investigating Nitrated Polycyclic Aromatic Hydrocarbon Developmental Toxicity

Creator:: Chlebowski, Anna C.
Abstract:: Polycyclic aromatic hydrocarbons (PAHs) are among the most widely known and studied environmental contaminants, originating from a range of natural and anthropogenic sources. PAHs are known to occur in the environment as complex mixtures, containing both unsubstituted PAHs, as well as a range of PAH derivatives. Among the less-studied of...
Resource Type:: Dissertation
Full Text:: contaminants, originating from a range of natural and anthropogenic sources. PAHs are known to occur in the

ScholarsArchive@OSU

Developmental neurobehavioral toxicity of bisphenol A in zebrafish (Danio rerio)

Transcriptomic approaches for discovering regenerative and developmental regulatory networks in zebrafish

Vitamin E and the alpha-tocopherol transfer protein during zebrafish embryogenesis

Chemical and biological approaches to identify vertebrate tissue regeneration pathways

Classifying Chemical Bioactivity by Coupling High-throughput Phenotypic Anchoring and Transcriptome Profiling in Zebrafish

Developmental toxicity of polycyclic aromatic hydrocarbons : defining mechanisms with systems-based transcriptional profiling

Developing rapid in vivo assays to investigate structure response relationships

Defining PAH and Oxygen-substituted PAH-dependent Developmental and Adult Toxicity in Zebrafish

Utilization of the Zebrafish Model for Investigating Nitrated Polycyclic Aromatic Hydrocarbon Developmental Toxicity

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