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Filtering by: Creator Tarkan, A. Serhan Advisor Traber, Maret G.

Vitamin E Protects Developmental Gene Expression and Metabolic Networks in Zebrafish Embryos

Creator:

Head, Brian A.

Abstract:

Vitamin E (VitE) is necessary for vertebrate embryonic development. VitE prevents lipid peroxidation (LPO), which requires detoxification by cellular antioxidant systems subsequently involving reducing power derived from energy metabolism. Thus, VitE protects metabolic networks in the developing embryo and the integrated gene expression networks compensating for and impaired by LPO-induced...

Resource Type:

Dissertation

Full Text:

ABSTRACT OF THE DISSERTATION OF Brian A. Head for the degree of Doctor of Philosophy in Molecular and
Embryogenesis is dependent upon 12-lipoxygenase, 5-lipoxygenase, and alpha-tocopherol to modulate polyunsaturated fatty acid status and the production of oxidized fatty acids in zebrafish, Embryogenesis is dependent upon 12-lipoxygenase, 5-lipoxygenase, and α-tocopherol to modulate polyunsaturated fatty acid status and the production of oxidized fatty acids in zebrafish

Creator:

Lebold, Katherine M.

Abstract:

Arachidonic acid (ARA) and docosahexaenoic acid (DHA) are polyunsaturated fatty acids required for proper embryonic development, specifically neurodevelopment. However, little is known regarding their conversion to other metabolites during embryogenesis. The oxidation of ARA gives rise to the biologically active eicosanoids and the oxidation of DHA gives rise to the...

Resource Type:

Masters Thesis

Full Text:

is required for proper embryonic development. Additionally, we hypothesize that α-tocopherol, a