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Filtering by: Alternative title ssim 4-H 6401 Remove constraint Alternative title ssim: 4-H 6401 Advisor Turker, Mitchell S. Remove constraint Advisor: Turker, Mitchell S.

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  • Spontaneous and enviornmental [sic] mutagenesis in mismatch repair deficient cells

    Creator:
    Shin-Darlak, Chi Y.
    Abstract:
    DNA damage, if not repaired, can become a mutation. Mutation accumulation is associated with initiation and progression of tumorigenesis. DNA mismatch repair (MMR) is required for maintaining genetic stability by repairing replication errors. Biochemical studies have shown that MMR also recognizes mismatch-causing DNA lesions, suggesting the role of MMR in...
    Resource Type:
    Dissertation
    Full Text:
    Page 1. Primers used to amplify and sequence mouse Aprt 33 2. 3. 4. Analysis of TCR in wild-type

  • Factors contributing to the formation of CC-->TT tandem mutations

    Creator:
    Skinner, Amy M.
    Abstract:
    The multistage model of carcinogenesis states that an accumulation of mutations in genes that are important for maintaining cellular homeostasis may lead to cancer. A specific type of mutation observed in particular types of cancer is the CC-->TT mutation found in the TP53 gene of patients with basal or squamous...
    Resource Type:
    Dissertation
    Full Text:
    4. Examining the role of sequence context on tandem mutation formation….. 67 Results