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Filtering by: Creator Jayaraman, A. Advisor Weller, Dwight D.

Design of B-form specific DNA binding oligonucleotide analogues : investigations of novel recognition moieties for triple helix formation

Creator:

Hogeland, Jane S.

Resource Type:

Dissertation

Full Text:

capable of forming triple helices by binding within the major groove of a DNA duplex target. While DNA
Synthesis and oligomerization of y,4-Diamino-2-oxo-1(2H)-pyrimidinepentanoic acid

Creator:

Nelson, Jeffrey Stephen

Abstract:

Described herein is the synthesis of an uncharged stereoregular oligonucleotide analog consisting of cytosine bases linked at specific intervals to a polyamide backbone derived from (L)-glutamic acid. Preparation of this analog entailed borane reduction of (L)- pyroglutamic acid to give optically pure lactam alcohol 9. Tosylation and alkylation with cytosine...

Resource Type:

Masters Thesis

Full Text:

intervals to a polyamide backbone derived from (L)-glutamic acid. Preparation of this analog entailed
Synthesis and oligomerization of Delta, 4-diamino-2-oxo-1(2H)-pyrimidinehexanoic acid

Creator:

Huang, Sung-ben

Resource Type:

Dissertation

Full Text:

- carboxylates 33a,b, prepared from L-a-aminoadipic acid by a slightly modification of the literature procedure