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Filtering by: Creator Wierzbicki%2C Igor H. Advisor White, James D. Committee Member Gable, Kevin P.

Studies toward the total synthesis of (+)-providencin

Creator:

Jana, Somnath

Abstract:

Studies toward the total synthesis of (+)-providencin (1), a highly oxygenated cembranoid dipterpene with a unique bicyclo[12.2.0]hexadecane skeleton and pronounced biological activity, are described. These studies resulted in the synthesis of advanced intermediates 320 and 332 which contain all of the carbon atoms of 1. In a first generation approach...

Resource Type:

Dissertation

Full Text:

to couple the two major fragments, 228 and 288, using palladium-catalyzed C-H activation of the
Total synthesis of phorboxazole A

Creator:

Lee, Tae Hee

Abstract:

The total synthesis of a highly potent cytotoxic marine natural product, phorboxazole A, is described. Both a palladium(II)-mediated and a palladium(II)-catalyzed intramolecular alkoxycarbonylation were used as key steps for the preparation of the two cis-2,6-disubstituted tetrahydropyran rings (C22-C26 and C11-C15) of phorboxazole A. The synthesis used a convergent approach involving...

Resource Type:

Dissertation

Full Text:

synthetic targets for total synthesis.2,3,4 2 O N O H H O O O O R1 H H H H N OO
Cis-2,5-diaminobicyclo[2.2.2]octane : a novel C₂-symmetric scaffold for asymmetric catalysis

Creator:

Shaw, Subrata

Abstract:

This thesis describes the development of a new enantioselective synthetic method employing chiral cis-2,5-diaminobicyclo[2.2.2]octane-based organometallic catalysts. The significance of this new method to organic synthesis is illustrated with preparation of enantioenriched products that are transformed to important pharmaceutical agents. Chapter 1 provides a brief historical overview of asymmetric catalysis, especially...

Resource Type:

Dissertation

Full Text:

Thalidomide (1) (R)-antiemetic (S)-teratogenic MeO Ni,_ ( -.I) ' N CI H Nexium (4) racemic: Prilosec OH H