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Filtering by: Creator Marsden, A. Dale Remove constraint Creator: Marsden, A. Dale Advisor White, James D. Remove constraint Advisor: White, James D. Decade 2000-2009 Remove constraint Decade: 2000-2009 Non-Academic Affiliation Oregon State University. Graduate School Remove constraint Non-Academic Affiliation: Oregon State University. Graduate School

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  • Total synthesis of phorboxazole A

    Creator:
    Lee, Tae Hee
    Abstract:
    The total synthesis of a highly potent cytotoxic marine natural product, phorboxazole A, is described. Both a palladium(II)-mediated and a palladium(II)-catalyzed intramolecular alkoxycarbonylation were used as key steps for the preparation of the two cis-2,6-disubstituted tetrahydropyran rings (C22-C26 and C11-C15) of phorboxazole A. The synthesis used a convergent approach involving...
    Resource Type:
    Dissertation
    Full Text:
    SYNTHESIS OF C1-C32 MACROLACTONE OF PHORBOXAZOLE A AN

  • Synthesis of marine natural products. part I, Cryptophycins-1, -3, -4, -24, and -29, part II, Polycavernoside A

    Creator:
    Robarge, Lonnie A.
    Resource Type:
    Dissertation
    Full Text:
    , -3, -4, -24, and -29, part II, Polycavernoside A. AN ABSTRACT OF THE DISSERTATION OF Lonnie A

  • Asymmetric synthesis of cyclopropanes via a "zipper reaction"

    Creator:
    Lincoln, Christopher M.
    Abstract:
    The rearrangement of a homoallyl cation to a cyclopropylcarbinyl cation is thought to play a role in the biogenesis of a variety of cyclopropane-containing natural products,¹ a hypothesis which has previously led to the design of successful biomimetic syntheses of several natural products.² The strategy underlying this approach to cyclopropane...
    Resource Type:
    Dissertation
    Full Text:
    Synthesis of Cyclopropanes via a "Zipper Reaction" Abstract approved: James D. White The rearrangement of

  • Synthesis of epothilones and epothilone analogues

    Creator:
    Sundermann, Kurt F.
    Abstract:
    A convergent synthesis of epothilone B that generates all seven of its asymmetric centers in a completely stereoselective fashion has been completed. Key reactions include an anti-Felkin aldol condensation to set the C6 and C7 stereochemistry, a directed α-hydroxylation to install the C15 (S)-hydroxyl substituent, and a Wittig condensation to...
    Resource Type:
    Dissertation
    Full Text:
    Epothilones and Epothilone Analocjues. Abstract approved: A convergent synthesis of epothilone B that

  • Total synthesis of (-)-7-epicylindrospermopsin

    Creator:
    Hansen, Joshua D.
    Abstract:
    The first asymmetric synthesis of (-)-7-epicylindrospermopsin via intramolecular nitrone cycloaddition is described. The synthesis utilized a convergent approach to prepare the cycloaddition precursor 176, which was assembled by condensation of hydroxylamine 175 with aldehyde 145. Hydroxylamine 175 was synthesized from ethylene glycol (166) in seven steps. Aldehyde 145 was completed...
    Resource Type:
    Dissertation
    Full Text:
    intramolecular nitrone cycloaddition is described. The synthesis utilized a convergent approach to prepare the

  • Total synthesis of indole alkaloids: pt. 1. Asymmetric synthesis of (-)-ibogamine. pt. 2. An approach toward the synthesis of koumine

    Creator:
    Choi, Younggi
    Abstract:
    PART I. The preparation of (-)-ibogamine (1) in fourteen steps from benzoquinone and in 10% overall yield is a powerful illustration of the value of the asymmetric Diels-Alder reaction as a starting point in a multistep synthesis. All four cycloadducts, 70, 77, 84 and 96, obtained with the (S)-BINOL-TiCl₂ complex...
    Resource Type:
    Dissertation
    Full Text:
    fourteen steps from benzoquinone and in 10% overall yield is a powerful illustration of the value of the