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Filtering by: Advisor White, James D. Degree Field Chemistry Rights Statement Copyright Not Evaluated Subject Antibiotics -- Synthesis

Synthetic studies on the macrolide antibiotic rutamycin B

Creator:

Wang, Shan

Resource Type:

Dissertation
Chiral synthesis of monic acid C

Creator:

Theramongkol, Parinya

Abstract:

Bromoalkoxylation of dihydropyran with bromine and 1-borneol, followed by dehydrobromination and epoxidation, afforded trans-2-1- bornyloxy-3,4-epoxytetrahydropyran as a major product. This was treated with sodium phenylselenide to give a 1:1 mixture of (2R,3R,4R)- 2-1-bornyloxy-3-hydroxy-4-phenylselenotetrahydropyran and its (2S,3S, 4S) diastereomer. Elimination of the selenoxide, derived from oxidation of the former with hydrogen...

Resource Type:

Dissertation