Index Catalog // ScholarsArchive@OSU

Studies toward the total synthesis of sanglifehrin A

Creator:: Suttisintong, Khomson
Abstract:: Studies toward synthesis of subunits of sanglifehrin A, an immunosuppressant featuring a highly substituted [5,5]-spirolactam moiety as well as a 22-membered macrocycle are described. The macrolactone contains a peptidic backbone characterized by an unusual [beta]-substituted (S)-piperazic acid and (S)-m-hydroxyphenylalanine units. These studies resulted in the synthesis of advanced intermediate 358...
Resource Type:: Dissertation
Full Text:: a peptidic backbone characterized by an unusual β−substituted (S)-piperazic acid and (S)-m

Part I : synthesis of azetidin-2-ones from pyrazolidin-3-ones ; Part II : synthesis of a subunit of the immunosuppressant FK-506

Creator:: Toske, Steven Gerald
Resource Type:: Dissertation
Full Text:: involved in the formation of 93 (Scheme 12). Me Me M e, , N N hv, Me0H, ii.... Me,N quartz filter 0

Approaches toward the asymmetric synthesis of pillaromycin A

Creator:: Nolen, Ernest G.
Resource Type:: Dissertation
Full Text:: % Stomatitis 80% *These received >500 mg/m 2 . in viscosity, thermal denaturation-renaturation, and optical

Approaches to the synthesis of trichothecenes

Creator:: Kim, No-soo
Resource Type:: Dissertation
Full Text:: . 12 Treatment of the trichothecene 47 with m-chloroperbenzoic acid resulted in 12,13-epoxytrichothec

Total synthesis of indole alkaloids: pt. 1. Asymmetric synthesis of (-)-ibogamine. pt. 2. An approach toward the synthesis of koumine

Creator:: Choi, Younggi
Abstract:: PART I. The preparation of (-)-ibogamine (1) in fourteen steps from benzoquinone and in 10% overall yield is a powerful illustration of the value of the asymmetric Diels-Alder reaction as a starting point in a multistep synthesis. All four cycloadducts, 70, 77, 84 and 96, obtained with the (S)-BINOL-TiCl₂ complex...
Resource Type:: Dissertation
Full Text:: Kuntiyong, Chang-Sun Lee, Nadine Lee, Tae-Hee Lee, Christopher M. Lincoln, Barton W. Phillips, Laura

Synthetic studies on the macrolide antibiotic rutamycin B

Creator:: Wang, Shan
Resource Type:: Dissertation
Full Text:: , Nick Drape la, Neal Green, Carla Hassler, Mark Holoboski, Randy Jackson, Scott Jeffrey, Scott Kemp

Studies toward the total synthesis of (+)-providencin

Creator:: Jana, Somnath
Abstract:: Studies toward the total synthesis of (+)-providencin (1), a highly oxygenated cembranoid dipterpene with a unique bicyclo[12.2.0]hexadecane skeleton and pronounced biological activity, are described. These studies resulted in the synthesis of advanced intermediates 320 and 332 which contain all of the carbon atoms of 1. In a first generation approach...
Resource Type:: Dissertation
Full Text:: (Scheme 1.10). Rubifolide (64) was then oxidized with m- chloroperbenzoic acid to isoepilophodione (93

Synthetic studies on natural products : Part I. The total synthesis of ±-euonyminol and ±-3,4-dideoxymaytol : Part II. The absolute configuration and enantioselective synthesis of curacin A

Creator:: Kim, Tae-Seong
Resource Type:: Dissertation
Full Text:: . The Total if _ -E in min 4-13- m. 1 P rt II. Th- A of to Configuration and Enantioselective

Cis-2,5-diaminobicyclo[2.2.2]octane : a novel C₂-symmetric scaffold for asymmetric catalysis

Creator:: Shaw, Subrata
Abstract:: This thesis describes the development of a new enantioselective synthetic method employing chiral cis-2,5-diaminobicyclo[2.2.2]octane-based organometallic catalysts. The significance of this new method to organic synthesis is illustrated with preparation of enantioenriched products that are transformed to important pharmaceutical agents. Chapter 1 provides a brief historical overview of asymmetric catalysis, especially...
Resource Type:: Dissertation
Full Text:: metal salts 33 2.2 Correlation between ionic radii of metal ions, N1-M-N2 angle and N-N separation in

Chiral synthesis of alcohols via asymmetric epoxidation

Creator:: Engebrecht, Jeffrey Ronald
Abstract:: Enantioselective epoxidation of crotyl alcohol, followed by a cuprate mediated methylation, gave a 1:1 mixture of (2S) -3- methyl -1,2- butanediol and (2R,3S)-2-methy1-1,3- butanediol. The latter was separated as its 2,4,6-trimethylbenzenesulfonate derivative and converted via the iodide to the corresponding phosphonium salt. The separated butanediol derivatives were independently transformed to...
Resource Type:: Masters Thesis
Full Text:: =pentuplet, h=hextuplet, m=multiplet, bs=broad singlet, etc., are used throughout. Carbon NMR spectra were

ScholarsArchive@OSU

Studies toward the total synthesis of sanglifehrin A

Part I : synthesis of azetidin-2-ones from pyrazolidin-3-ones ; Part II : synthesis of a subunit of the immunosuppressant FK-506

Approaches toward the asymmetric synthesis of pillaromycin A

Approaches to the synthesis of trichothecenes

Total synthesis of indole alkaloids: pt. 1. Asymmetric synthesis of (-)-ibogamine. pt. 2. An approach toward the synthesis of koumine

Synthetic studies on the macrolide antibiotic rutamycin B

Studies toward the total synthesis of (+)-providencin

Synthetic studies on natural products : Part I. The total synthesis of ±-euonyminol and ±-3,4-dideoxymaytol : Part II. The absolute configuration and enantioselective synthesis of curacin A

Cis-2,5-diaminobicyclo[2.2.2]octane : a novel C₂-symmetric scaffold for asymmetric catalysis

Chiral synthesis of alcohols via asymmetric epoxidation

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