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Filtering by: Creator Coakley, J. A., Jr. Remove constraint Creator: Coakley, J. A., Jr. Advisor White, James D. Remove constraint Advisor: White, James D. Degree Level Master's Remove constraint Degree Level: Master's

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  • Synthesis of a model of the spiroketal portion of avermectin B

    Creator:
    Warrier, Ulhas S.
    Abstract:
    Avermectin Bia is a member of a class of medicinally important natural products known for its potent antiparasitic activity and interesting structural features. In this thesis, synthesis of a model for the spiroketal portion of the avermectins is presented. Oxidation of (S)-2-methylbutanol, followed by a stereoselective chromium mediated reaction with...
    Resource Type:
    Masters Thesis
    Full Text:
    J 0 Me Me 24 K 0 Et Me PYrr 1-12 CO Il O Figure 2. Structures of a Milbemycins. H--'"..**% O