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Filtering by: Creator Johnson, Colin P. Advisor White, James D. Subject Immunosuppressive agents -- Synthesis

Synthetic approaches to the tricarbonyl subunit of rapamycin

Creator:

LaMunyon, James B.

Abstract:

Rapamycin (5) was isolated in 1975 from the soil bacteria Streptomyces hygroscopicus and its structure was determined from spectroscopic techniques and an x-ray crystallographic analysis. Although it was initially found to exhibit antibiotic activity, it was subsequently shown to possess potent immunosuppressive activity as well. Three approaches to the synthesis...

Resource Type:

Masters Thesis

Full Text:

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Synthetic studies n bioactive natural products. Part I, An approach towards the nootrophic agent huperzine A. Part II, Synthesis of the tricarbonyl subunit of rapamycin

Creator:

Jeffrey, Scott C.

Resource Type:

Dissertation

Full Text:

Members Past and Present Alan Johnson, No Soo Kim, Kraig Yager, Steven Toske, Hyunik Shin, Frank