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Filtering by: Subject Antibiotics -- Synthesis Advisor White, James D.

Studies toward the total synthesis of sanglifehrin A

Creator:

Suttisintong, Khomson

Abstract:

Studies toward synthesis of subunits of sanglifehrin A, an immunosuppressant featuring a highly substituted [5,5]-spirolactam moiety as well as a 22-membered macrocycle are described. The macrolactone contains a peptidic backbone characterized by an unusual [beta]-substituted (S)-piperazic acid and (S)-m-hydroxyphenylalanine units. These studies resulted in the synthesis of advanced intermediate 358...

Resource Type:

Dissertation
Synthetic studies on the macrolide antibiotic rutamycin B

Creator:

Wang, Shan

Resource Type:

Dissertation

Full Text:

Synthetic studies on the macrolide antibiotic rutamycin B AN
Part I : synthesis of azetidin-2-ones from pyrazolidin-3-ones ; Part II : synthesis of a subunit of the immunosuppressant FK-506

Creator:

Toske, Steven Gerald

Resource Type:

Dissertation

Full Text:

nitrosative deamination with N,N-diphenylnitrosamine. Synthesis of the known precursor 220 to the antibiotic
The synthesis of macrolactones from [omega]-hydroxyacyl xanthates

Creator:

Akella, Annapoorna

Resource Type:

Masters Thesis

Full Text:

within the molecule. 0 0 O OH 1 2 Examples of 14-membered macrolides are the antibiotic substances
Chiral synthesis of monic acid C

Creator:

Theramongkol, Parinya

Abstract:

Bromoalkoxylation of dihydropyran with bromine and 1-borneol, followed by dehydrobromination and epoxidation, afforded trans-2-1- bornyloxy-3,4-epoxytetrahydropyran as a major product. This was treated with sodium phenylselenide to give a 1:1 mixture of (2R,3R,4R)- 2-1-bornyloxy-3-hydroxy-4-phenylselenotetrahydropyran and its (2S,3S, 4S) diastereomer. Elimination of the selenoxide, derived from oxidation of the former with hydrogen...

Resource Type:

Dissertation

Full Text:

observed low toxicity of the antibiotic in mammals. (a) (b) Hydrophobic HO OH Hydrophobic co