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Filtering by: Creator Edson, James B. Remove constraint Creator: Edson, James B. Advisor White, James D. Remove constraint Advisor: White, James D.

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  • Synthetic studies on the macrolide antibiotic rutamycin B

    Creator:
    Wang, Shan
    Resource Type:
    Dissertation
    Full Text:
    Synthetic studies on the macrolide antibiotic rutamycin B AN

  • The total synthesis of (-)- acorenone B ; Approaches to the synthesis of mycosporin (P 310)

    Creator:
    Ruppert, John Fredrick
    Resource Type:
    Dissertation
    Full Text:
    The total synthesis of (-)- acorenone B ; Approaches to

  • Synthesis of a model of the spiroketal portion of avermectin B

    Creator:
    Warrier, Ulhas S.
    Abstract:
    Avermectin Bia is a member of a class of medicinally important natural products known for its potent antiparasitic activity and interesting structural features. In this thesis, synthesis of a model for the spiroketal portion of the avermectins is presented. Oxidation of (S)-2-methylbutanol, followed by a stereoselective chromium mediated reaction with...
    Resource Type:
    Masters Thesis
    Full Text:
    avermectin B AN ABSTRACT OF THE THESIS OF Ulhas S. Warrier for the degree of Master of Science in

  • Synthetic approaches to the tricarbonyl subunit of rapamycin

    Creator:
    LaMunyon, James B.
    Abstract:
    Rapamycin (5) was isolated in 1975 from the soil bacteria Streptomyces hygroscopicus and its structure was determined from spectroscopic techniques and an x-ray crystallographic analysis. Although it was initially found to exhibit antibiotic activity, it was subsequently shown to possess potent immunosuppressive activity as well. Three approaches to the synthesis...
    Resource Type:
    Masters Thesis
    Full Text:
    AN ABSTRACT OF THE THESIS OF James B. LaMunyon for the degree

  • The synthesis of trisporic acids

    Creator:
    Prisbylla, Michael Paul
    Abstract:
    A total synthesis of the fungal hormones, trisporic acids A and B, is described, starting from a -methyltetronic acid 34. A Robinson annelation of 34 with ethyl vinyl ketone affords the lactone 33. Treatment of 33 with N-bromosuccinimide gave 97, which was hydrolyzed to the lactol 103. The reaction of...
    Resource Type:
    Dissertation
    Full Text:
    13, 1977 Title: THE SYNTHESIS OF TRISPORIC ACIDS Abstract approved: Redacted for Privacy Dr. James

  • Synthesis of epothilones and epothilone analogues

    Creator:
    Sundermann, Kurt F.
    Abstract:
    A convergent synthesis of epothilone B that generates all seven of its asymmetric centers in a completely stereoselective fashion has been completed. Key reactions include an anti-Felkin aldol condensation to set the C6 and C7 stereochemistry, a directed α-hydroxylation to install the C15 (S)-hydroxyl substituent, and a Wittig condensation to...
    Resource Type:
    Dissertation
    Full Text:
    Epothilones and Epothilone Analocjues. Abstract approved: A convergent synthesis of epothilone B that

  • Approaches to the total synthesis of verrucarol

    Creator:
    Hill, David E. (David Edwin) 1954-
    Abstract:
    Verrucarol is the sesquiterpene portion of a number of macrocyclic di- and triesters of potential medicinal importance. In this study, a novel approach to the synthesis of this fungal metabolite is presented. An A-B-C route was investigated in which C-3 and C-4 of the C-ring were emplaced using a [2+2]...
    Resource Type:
    Dissertation
    Full Text:
    privacy (Pr. James D. White Verrucarol is the sesquiterpene portion of a number of macrocyclic di- and

  • Synthesis of two subunits of avermectin B1a

    Creator:
    Dantanarayana, Anura Pathmasiri
    Abstract:
    Avermectins are a group of potent anthelmintic agents produced by Streptomyces avermitilis. They are active at extremely low dosages and are now in commercial use. In this study, the synthesis of two segments of avermectin B[subscript 1a] are described. The synthesis of the hexahydrobenzofuran subunit (segment A) began with the...
    Resource Type:
    Dissertation
    Full Text:
    approved: Redacted for privacy (it James D. White Avermectins are a group of potent anthelmintic agents

  • Tandem intramolecular photocycloaddition-retro-Mannich fragmentation as a route to indole and oxindole

    Creator:
    Li, Yang
    Abstract:
    Irradiation of a tryptamine linked through its side-chain nitrogen to an alkylidene malonate residue results in an intramolecular [2 + 2] cycloaddition to the indole 2,3-double bond. The resultant cyclobutane undergoes spontaneous retro-Mannich fission to produce a spiro[indoline-3,3-pyrrolenine] with relative configuration defined by the orientation of substituents in the transient...
    Resource Type:
    Dissertation
    Full Text:
    approved: James D. White

  • Studies towards the total synthesis of (-)-gymnodimine

    Creator:
    Wang, Guoqiang
    Abstract:
    Studies towards the total synthesis of (-)-gymnodimine (1), a marine neurotoxin with a unique molecular architecture and pronounced biological activity, are described. These studies resulted in a convergent approach to the advanced intermediate 315, containing the C3-C32 section of 1. Two synthetic routes were developed to construct the tetrahydrofuran subunit...
    Resource Type:
    Dissertation
    Full Text:
    Total Synthesis of ()-Gvmnodimine Abstract James D. White Studies towards the total synthesis of