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Cis-2,5-diaminobicyclo[2.2.2]octane : a novel C₂-symmetric scaffold for asymmetric catalysis

Creator:: Shaw, Subrata
Abstract:: This thesis describes the development of a new enantioselective synthetic method employing chiral cis-2,5-diaminobicyclo[2.2.2]octane-based organometallic catalysts. The significance of this new method to organic synthesis is illustrated with preparation of enantioenriched products that are transformed to important pharmaceutical agents. Chapter 1 provides a brief historical overview of asymmetric catalysis, especially...
Resource Type:: Dissertation
Full Text:: [2.2.2]octane: A Novel C2-Symmetric Scaffold for Asymmetric Catalysis Abstract approved: James D

Approaches toward the asymmetric synthesis of pillaromycin A

Creator:: Nolen, Ernest G.
Resource Type:: Dissertation
Full Text:: Ernest G. Nolen Jr. ACKNOWLEDGEMENTS I would like to thank Dr. James D. White for his direction and

Cyclization of olefinic β-ketoesters. An approach to the synthesis of aplysistatin

Creator:: Skeean, Richard William
Resource Type:: Dissertation
Full Text:: . An Approach to the Synthesis of Aplysistatin Abstract Approved: Redacted for privacy 7/ Dr. James D

Synthesis of marine natural products. part I, Cryptophycins-1, -3, -4, -24, and -29, part II, Polycavernoside A

Creator:: Robarge, Lonnie A.
Resource Type:: Dissertation
Full Text:: A. Abstract approved:, James D. White Part 1: A convergent synthesis of cryptophycins has been

Tandem intramolecular photocycloaddition-retro-Mannich fragmentation as a route to indole and oxindole

Creator:: Li, Yang
Abstract:: Irradiation of a tryptamine linked through its side-chain nitrogen to an alkylidene malonate residue results in an intramolecular [2 + 2] cycloaddition to the indole 2,3-double bond. The resultant cyclobutane undergoes spontaneous retro-Mannich fission to produce a spiro[indoline-3,3-pyrrolenine] with relative configuration defined by the orientation of substituents in the transient...
Resource Type:: Dissertation
Full Text:: approved: James D. White

Studies toward the total synthesis of (+)-providencin

Creator:: Jana, Somnath
Abstract:: Studies toward the total synthesis of (+)-providencin (1), a highly oxygenated cembranoid dipterpene with a unique bicyclo[12.2.0]hexadecane skeleton and pronounced biological activity, are described. These studies resulted in the synthesis of advanced intermediates 320 and 332 which contain all of the carbon atoms of 1. In a first generation approach...
Resource Type:: Dissertation
Full Text:: approved: _____________________________________________________ James D. White Studies toward

Approaches to the synthesis of trichothecane sesquiterpenes

Creator:: Thomas, James Anthony
Resource Type:: Dissertation
Full Text:: sesquiterpenes AN ABSTRACT OF THE THESIS OF James Anthony Thomas for the degree of Doctor of Philosophy in

Synthetic approaches to the tricarbonyl subunit of rapamycin

Creator:: LaMunyon, James B.
Abstract:: Rapamycin (5) was isolated in 1975 from the soil bacteria Streptomyces hygroscopicus and its structure was determined from spectroscopic techniques and an x-ray crystallographic analysis. Although it was initially found to exhibit antibiotic activity, it was subsequently shown to possess potent immunosuppressive activity as well. Three approaches to the synthesis...
Resource Type:: Masters Thesis
Full Text:: AN ABSTRACT OF THE THESIS OF James B. LaMunyon for the degree

Alkylation studies on Hagemann's ester: an approach to the synthesis of the trisporic acids

Creator:: Sung, Wing Lam
Abstract:: Sequential alkylation of Hagemann's ester with methyl and methallyl halides has been studied. Treatment of Hagemann's ester with methyl iodide and sodium ethoxide gave a mixture of 21 and 25 in a ratio of 4:1. Alkylation of 21 with methallyl chloride and potassium t-butoxide afforded a mixture of 37 and...
Resource Type:: Masters Thesis
Full Text:: Privacy James D. White Sequential alkylation of Hagemann's ester with methyl and methallyl halides has

The synthesis of macrolactones from [omega]-hydroxyacyl xanthates

Creator:: Akella, Annapoorna
Resource Type:: Masters Thesis
Full Text:: Xanthates Redacted for Privacy Abstract approved: James D. White The synthesis of macrolactones from 0

ScholarsArchive@OSU

Cis-2,5-diaminobicyclo[2.2.2]octane : a novel C₂-symmetric scaffold for asymmetric catalysis

Approaches toward the asymmetric synthesis of pillaromycin A

Cyclization of olefinic β-ketoesters. An approach to the synthesis of aplysistatin

Synthesis of marine natural products. part I, Cryptophycins-1, -3, -4, -24, and -29, part II, Polycavernoside A

Tandem intramolecular photocycloaddition-retro-Mannich fragmentation as a route to indole and oxindole

Studies toward the total synthesis of (+)-providencin

Approaches to the synthesis of trichothecane sesquiterpenes

Synthetic approaches to the tricarbonyl subunit of rapamycin

Alkylation studies on Hagemann's ester: an approach to the synthesis of the trisporic acids

The synthesis of macrolactones from [omega]-hydroxyacyl xanthates

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