We are developing a flavin-containing (Fmo) knock-out mouse for Fmo2 that will be utilized to elucidate the role of active human FMO isoform 2 (FMO2.1) in xenobiotic metabolism and toxicity. Since FMO2 is primarily expressed in lung this will provide information on how 27% of African-Americans and 5% of Hispanics...
Non-alcoholic Steatohepatitis (NASH) is an emerging form of liver disease associated with obesity, type II diabetes and dyslipidemia. As the prevalence of these metabolic conditions increases, so too has the occurrence of NASH in all sectors of the population. The pathology of this disease is similar to its alcoholic form,...