Index Catalog // ScholarsArchive@OSU

Flavin-containing monooxygenase, tissue specific regulation in rabbit

Creator:: Lee, Min-young
Resource Type:: Dissertation
Full Text:: ) Throughout Gestation in Rabbits Min-Young Lee and David E. Williams Toxicology Program Oregon State

Sex and life stage sensitivity of rainbow trout to xenoestrogens

Creator:: Carlson, David B., 1970-
Abstract:: Numerous natural and anthropogenic chemicals interact with endocrine systems of animals. The most widely studied of these endocrine active chemicals (EACs) are estrogen receptor agonists and antagonists. Because of the many important roles of estrogens in animals, xenoestrogens have the potential to impact environmental health. It has been proposed that...
Resource Type:: Dissertation
Full Text:: xenoestrogens AN ABSTRACT OF THE THESIS OF David B. Carlson for the degree of Doctor of Philosophy in

Mechanisms of inhibition of chemical carcinogenesis by indole-3- carbinol in the rat

Creator:: Stresser, David M.
Resource Type:: Dissertation
Full Text:: indole-3- carbinol in the rat AN ABSTRACT OF THE THESIS OF David M. Stresser for the degree of Doctor

Critical windows of transplacental carcinogenesis : identifying efficacious approaches to chemoprevention with dietary phytochemicals

Creator:: Castro, David J.
Abstract:: Polycyclic aromatic hydrocarbons (PAHs) are a re-emerging class of environmental pollutants. The persistent nature of these highly toxic compounds along with their ubiquity in the environment creates an unavoidable route of exposure. The developing fetus and neonate are a particularly susceptible population due to their incomplete complement of xenobiotic metabolizing...
Resource Type:: Dissertation
Full Text:: DISSERTATION OF David J. Castro for the degree of Doctor of Philosophy in Toxicology presented on February

Modulation of chemically-induced hepatocarcinogenesis by indole-3-carbinol : mechanisms and species comparison

Creator:: Oganesian, Aram
Abstract:: There is plenty of evidence from epidemiology studies supporting a link between certain components in the human diet and cancer incidence. It is estimated that 3-4 million annual cases of cancer could be prevented worldwide just by changing dietary habits. In parts of the world where vegetables and fruits constitute...
Resource Type:: Dissertation
Full Text:: Comparison Abstract approved: David E. Williams There is plenty of evidence from epidemiology studies

Identification and characterization of flavin-containing monooxygenase isoform 2 (FMO2) in Rhesus monkey and examination of a human FMO2 polymorphism

Creator:: Yueh, Mei-Fei
Abstract:: Flavin-containing monooxygenase (FMO, EC1.14.13.8) comprises a family of xenobiotic-metabolizing enzymes that catalyze the oxygenation of a wide variety of xenobiotics, most commonly nitrogen and sulfur. Mammals express five different FMOs in a species- and tissue- specific manner. FMO2, is expressed predominantly in lung and differs from other FMOs in that...
Resource Type:: Dissertation
Full Text:: (FMO2) in Rhesus Monkey and Examination of an Human FMO2 Polymorphism. Abstract Approved: David E

Developmental and dietary regulation of flavin-containing monooxygenase

Creator:: Su, Shelley A. Larsen
Resource Type:: Dissertation
Full Text:: Monooxygenase. Abstract approved: David E. Williams Flavin-containing monooxygenases (FMOs) are a family of

Dehydroepiandrosterone carcinogenesis and tumor modulating effects in trout

Creator:: Orner, Gayle A.
Resource Type:: Dissertation
Full Text:: Effects in Trout. Abstract approved: David E. Williams Peroxisome proliferators (PPs) are nongenotoxic

Chronic exposure of rodents to indole-3-carbinol and 3,3'-diindolylmethane : implications for drug metabolism, chemoprevention and human health

Creator:: Leibelt, Dustin A.
Abstract:: Indole-3-carbinol (I3C) is a naturally occurring plant alkaloid, found in significant concentrations in cruciferous vegetables such as broccoli and Brussels sprouts. I3C is an unstable compound that undergoes rapid oligomerization in an acidic environment to form higher order condensation products (I3C-ACPs), such as 3-3'-diindolylmethane (DIM). Both I3C and DIM are...
Resource Type:: Dissertation
Full Text:: , Chemoprevention and Human Health. Abstract David E. Williams Indole-3-carbinol (13 C) is a naturally occurring

Indole-3-carbinol and 3,3'-diindolylmethane : relative potency as modulators of drug metabolism and carcinogenesis

Creator:: Katchamart, Sirinmas
Abstract:: Indole-3-carbinol (I3C), the most abundant metabolite of glucobrassicins, is found in cruciferous vegetables such as broccoli, Brussels sprouts, cabbage and cauliflower. I3C has been shown to have anticarcinogenic activity against many chemical carcinogens in multiple target organs in animal models. However, the anticarcinogenic activity of I3C is considered indirect since...
Resource Type:: Dissertation
Full Text:: Carcinogenesis. Abstract approved: David B. Williams Indole-3-carbinol (13C), the most abundant metabolite of

Application of toxicogenomics to determine mechanism of tumor modulation by dietary indole phytochemicals in hepatocellular carcinoma

Creator:: Tilton, Susan C.
Abstract:: Indole-3-carbinol (I3C) and 3,3'-diindolylmethane (DIM), a primary I3C derivative in vivo, are known chemopreventive agents available as dietary supplements. I3C was found to suppress or enhance tumors in several animal models. Chemoprotection is attributed to the ability of indoles to alter carcinogen metabolism effectively blocking initiation. However, mechanisms for enhancement...
Resource Type:: Dissertation
Full Text:: Carcinoma. Abstract approved. David E. Williams Indole-3-carbinol (13C) and 3,3'-diindolylmethane (DIM), a

Indole-3-carbinol in the maternal diet provides chemoprotection for the fetus against transplacental carcinogenesis by dibenzo[a,l]pyrene in the B6 129 mouse model : role of the Aryl Hydrocarbon Receptor

Creator:: Yu, Zhen
Abstract:: Lymphomas and leukemias are the most common cancer in children and young adults and in utero exposure to carcinogens may contribute to the etiology of these cancers. A polycyclic aromatic hydrocarbon (PAH), dibenzo[a,l]pyrene (DBP), was administered to pregnant mice (15 mg/Kg b.w., gavage) on gestation day 17. Significant mortalities in...
Resource Type:: Dissertation
Full Text:: , Mohaiza Dashwood, Barbara McVicar, Dr. Rong Wang, Dr. David Yu, JungA Lee, Dr. John Mata, Dr. Doolalai

Characterization of androgenic and estrogenic responses in the rainbow trout by comparing liver slice to whole animal studies

Creator:: Shilling, Adam D.
Resource Type:: Dissertation
Full Text:: Animal Studies. Abstract approved: David E. Williams The disruption of the critical balance between

Developmental regulation of flavin-containing monooxygenase (FMO) form 1 and form 2 mRNA in fetal and neonatal rabbit

Creator:: Yueh, Mei-Fei
Abstract:: The mammalian FMO represents a multigene family which oxygenates a large number of xenobiotics. No physiological role has been determined for FMO, although synthesis of disulfide bonds and detoxification of dietary chemicals have been suggested. Five FMO gene subfamilies, each containing a single gene, have been identified. In this study,...
Resource Type:: Masters Thesis
Full Text:: . Abstract approved: David E. Williams The mammalian FMO represents a multigene family which oxygenates

The inhibitory mechanisms of indole-3-carbinol and B-naphthoflavone against aflatoxin B1-initiated hepatocarcinogenesis in rainbow trout

Creator:: Takahashi, Naoko
Resource Type:: Dissertation
Full Text:: -Initiated Hepatocarcinogenesis in Rainbow Trout. Abstract Approved: _ David E. Williams

Antimutagenic potency of wheat grain and berry extracts in vitro and anticarcinogenicity of wheat grain in vivo

Creator:: Yu, Zhen
Abstract:: The antimutagenic potency of wheat grain and berry extracts was studied in vitro against several heterocyclic amines (HCAs) using the Salmonella mutagenicity assay and the anticarcinogencity of wheat grain was studied in vivo using the rat colonic aberrant crypt focus assay. Wheat bran, which binds HCAs in vitro, as well...
Resource Type:: Masters Thesis
Full Text:: and Berry Extracts in vitro and Anticarcinogenicity of Wheat Grain in vivo Abstract approved David

Flavin-containing monooxygenase : metabolism and toxicity of anti-tuberculosis drug ethionamide in lung

Creator:: Singh, Priti B.
Abstract:: Multiple drug resistance (MDR) Tuberculosis (TB), leads to increased use of “second-line” drugs; one of the most effective is ethionamide (ETA). ETA is a prodrug metabolized by a mycobacterial flavin-containing monooxygenase (EtaA) as well human flavin-containing monooxygenases (FMOs). Of the five functional FMOs of humans, FMOs 1, 2, and 3...
Resource Type:: Masters Thesis
Full Text:: Abstract approved: David E. Williams Multiple drug resistance (MDR) Tuberculosis (TB

Functional consequences of microRNA regulation by polycyclic aromatic hydrocarbons in 3D human bronchial epithelial cells

Creator:: Mans, Michael-Andres D.
Abstract:: Polycyclic aromatic hydrocarbons (PAHs) are a class of contaminants ubiquitous in the environment and result from the incomplete combustion of fossil fuels. Many PAHs have been identified as procarcinogenic, and are metabolized to form DNA adducts; however, other mechanisms also may contribute to toxicity and help explain differences in toxicity...
Resource Type:: Undergraduate Thesis
Full Text:: _____________________________________________________ _______________ David Williams, Environmental and Molecular Toxicology

ScholarsArchive@OSU

Flavin-containing monooxygenase, tissue specific regulation in rabbit

Sex and life stage sensitivity of rainbow trout to xenoestrogens

Mechanisms of inhibition of chemical carcinogenesis by indole-3- carbinol in the rat

Critical windows of transplacental carcinogenesis : identifying efficacious approaches to chemoprevention with dietary phytochemicals

Modulation of chemically-induced hepatocarcinogenesis by indole-3-carbinol : mechanisms and species comparison

Identification and characterization of flavin-containing monooxygenase isoform 2 (FMO2) in Rhesus monkey and examination of a human FMO2 polymorphism

Developmental and dietary regulation of flavin-containing monooxygenase

Dehydroepiandrosterone carcinogenesis and tumor modulating effects in trout

Chronic exposure of rodents to indole-3-carbinol and 3,3'-diindolylmethane : implications for drug metabolism, chemoprevention and human health

Indole-3-carbinol and 3,3'-diindolylmethane : relative potency as modulators of drug metabolism and carcinogenesis

Application of toxicogenomics to determine mechanism of tumor modulation by dietary indole phytochemicals in hepatocellular carcinoma

Indole-3-carbinol in the maternal diet provides chemoprotection for the fetus against transplacental carcinogenesis by dibenzo[a,l]pyrene in the B6 129 mouse model : role of the Aryl Hydrocarbon Receptor

Characterization of androgenic and estrogenic responses in the rainbow trout by comparing liver slice to whole animal studies

Developmental regulation of flavin-containing monooxygenase (FMO) form 1 and form 2 mRNA in fetal and neonatal rabbit

The inhibitory mechanisms of indole-3-carbinol and B-naphthoflavone against aflatoxin B1-initiated hepatocarcinogenesis in rainbow trout

Antimutagenic potency of wheat grain and berry extracts in vitro and anticarcinogenicity of wheat grain in vivo

Flavin-containing monooxygenase : metabolism and toxicity of anti-tuberculosis drug ethionamide in lung

Functional consequences of microRNA regulation by polycyclic aromatic hydrocarbons in 3D human bronchial epithelial cells

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