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Filtering by: Creator Chung, Po-luen Advisor Williams, David E.

Chronic exposure of rodents to indole-3-carbinol and 3,3'-diindolylmethane : implications for drug metabolism, chemoprevention and human health

Creator:

Leibelt, Dustin A.

Abstract:

Indole-3-carbinol (I3C) is a naturally occurring plant alkaloid, found in significant concentrations in cruciferous vegetables such as broccoli and Brussels sprouts. I3C is an unstable compound that undergoes rapid oligomerization in an acidic environment to form higher order condensation products (I3C-ACPs), such as 3-3'-diindolylmethane (DIM). Both I3C and DIM are...

Resource Type:

Dissertation

Full Text:

mice. Carcinogenesis 12, 1571-1574. Cha, Y.-N., Thompson, D.C., Heine, H.S., and Chung, J.-H. (1985
Mechanisms of inhibition of chemical carcinogenesis by indole-3- carbinol in the rat

Creator:

Stresser, David M.

Resource Type:

Dissertation

Full Text:

another study, the route of administration of AFB1 (ip or po) did not affect levels of hepatic DNA
The inhibitory mechanisms of indole-3-carbinol and B-naphthoflavone against aflatoxin B1-initiated hepatocarcinogenesis in rainbow trout

Creator:

Takahashi, Naoko

Resource Type:

Dissertation

Full Text:

. (1989) In vivo disposition of the natural anti-carcinogen indole-3-carbinol after po administration to
Application of toxicogenomics to determine mechanism of tumor modulation by dietary indole phytochemicals in hepatocellular carcinoma

Creator:

Tilton, Susan C.

Abstract:

Indole-3-carbinol (I3C) and 3,3'-diindolylmethane (DIM), a primary I3C derivative in vivo, are known chemopreventive agents available as dietary supplements. I3C was found to suppress or enhance tumors in several animal models. Chemoprotection is attributed to the ability of indoles to alter carcinogen metabolism effectively blocking initiation. However, mechanisms for enhancement...

Resource Type:

Dissertation