Index Catalog // ScholarsArchive@OSU

The 2-Hydroxyestrone to 16α-Hydroxyestrone Ratio in Human Urine as a Biomarker of Cancer Chemoprevention Following Exposure to Brussels Sprouts and the Phytochemical, 3,3’-Diindolylmethane (DIM)

Creator:: Chen, Danny
Abstract:: Estrogen is a sex hormone responsible for the development and regulation of the reproductive system and secondary sex characteristics. They also play a critical role in the development of breast and uterine cancer. The formation of agonistic metabolites of estrogen, especially 16α-hydroxyestrone, have been found to have cancer-inducing effects meanwhile...
Resource Type:: Honors College Thesis
Full Text:: ) Abstract approved: _____________________________________________________ David E. Williams

Genotyping Cytochrome P450 1B1*3(Phase I) and Glutathione S-transferase Mu 1 null (Phase II), Metabolizing Enzymes in a [14C]Benzo[a]pyrene Human Micro Dosing Study

Creator:: Luo, Yun L.
Abstract:: Polycyclic Aromatic Hydrocarbons (PAHs) have been studied for their carcinogenic toxicity. PAHs are formed by incomplete carbon combustion. Benzo[a]pyrene (BaP) is an IARC classified Class 1 Human carcinogenic PAH. New studies are conducted to gain a better understanding of PAHs and how to reduce exposure. Glutathione S-transferase M 1 (GSTM1...
Resource Type:: Honors College Thesis
Full Text:: _________________________________________________________________________ David E. Williams , Mentor, representing Environmental and Molecular Toxicology/Linus Pauling

Sulforaphane Regulation of LncRNA in a Transplacental Nrf2 Knockout Mouse Model Exposed to Dibenzo[def,p]chrysene

Creator:: Patel, Karan A.
Abstract:: Dibenzo[def,p]chrysene (DBC) is a highly potent, but less prevalent, environmental carcinogen belonging to a class of compounds known as Polycyclic Aromatic Hydrocarbons (PAHs). They are highly ubiquitous and arise as a byproduct of natural and anthropogenic combustion processes. Previous studies have documented carcinogenic effects upon in utero exposure of PAHs....
Resource Type:: Honors College Thesis
Full Text:: : ______________________________________________________________ David E. Williams Dibenzo[def,p]chrysene (DBC) is a highly potent, but less prevalent

Characterization of a Transgenic Mouse for Human Cytochrome P450 1B1 (CYP1B1)

Creator:: You, Hyekyoung Hannah
Abstract:: Cytochrome P450 1B1 (Cyp1B1) is a xenobiotic metabolizing enzyme, responsible for polycyclic aromatic hydrocarbon (PAH) oxidative metabolism. CYP1B1 metabolically activates several species of environmentally relevant procarcinogenic PAHs to reactive carcinogens. PAHs are aryl hydrocarbon receptor (AhR) agonists, leading to CYP1B1 upregulation. Though CYP1B1 is highly conserved across species, wild type...
Resource Type:: Honors College Thesis
Full Text:: . Abstract approved: ______________________________________________________ David E. Williams

Alterations in the lung miRNA profile of newborns and adult onset lung cancer in mice transplacentally exposed to the environmental contaminant dibenzo[def,p]chrysene

Creator:: Sampson, David
Abstract:: Lung cancer in humans is an adult-onset disease. It is the number one cause of cancer mortality for both men and women and has a poor (15%) survival rate. Biological markers of the disease would allow for early diagnosis and treatment. The specific aims of this research project were to...
Resource Type:: Undergraduate Thesis and Presentation

Flavin-containing monooxygenase : metabolism and toxicity of anti-tuberculosis drug ethionamide in lung

Creator:: Singh, Priti B.
Abstract:: Multiple drug resistance (MDR) Tuberculosis (TB), leads to increased use of “second-line” drugs; one of the most effective is ethionamide (ETA). ETA is a prodrug metabolized by a mycobacterial flavin-containing monooxygenase (EtaA) as well human flavin-containing monooxygenases (FMOs). Of the five functional FMOs of humans, FMOs 1, 2, and 3...
Resource Type:: Masters Thesis
Full Text:: Abstract approved: David E. Williams Multiple drug resistance (MDR) Tuberculosis (TB

Flavin-containing monooxygenase, tissue specific regulation in rabbit

Creator:: Lee, Min-young
Resource Type:: Dissertation
Full Text:: Regulation in Rabbit. Abstract approved: Redacted for Privacy David E. Williams One well known

Mechanisms of inhibition of chemical carcinogenesis by indole-3- carbinol in the rat

Creator:: Stresser, David M.
Resource Type:: Dissertation
Full Text:: Carcinogenesis by Indo le-3- Carbinol in the Rat Abstract approved: David E. Williams There are striking

Dehydroepiandrosterone carcinogenesis and tumor modulating effects in trout

Creator:: Orner, Gayle A.
Resource Type:: Dissertation
Full Text:: Effects in Trout. Abstract approved: David E. Williams Peroxisome proliferators (PPs) are nongenotoxic

Developmental and dietary regulation of flavin-containing monooxygenase

Creator:: Su, Shelley A. Larsen
Resource Type:: Dissertation
Full Text:: Monooxygenase. Abstract approved: David E. Williams Flavin-containing monooxygenases (FMOs) are a family of

ScholarsArchive@OSU

The 2-Hydroxyestrone to 16α-Hydroxyestrone Ratio in Human Urine as a Biomarker of Cancer Chemoprevention Following Exposure to Brussels Sprouts and the Phytochemical, 3,3’-Diindolylmethane (DIM)

Genotyping Cytochrome P450 1B1*3(Phase I) and Glutathione S-transferase Mu 1 null (Phase II), Metabolizing Enzymes in a [14C]Benzo[a]pyrene Human Micro Dosing Study

Sulforaphane Regulation of LncRNA in a Transplacental Nrf2 Knockout Mouse Model Exposed to Dibenzo[def,p]chrysene

Characterization of a Transgenic Mouse for Human Cytochrome P450 1B1 (CYP1B1)

Alterations in the lung miRNA profile of newborns and adult onset lung cancer in mice transplacentally exposed to the environmental contaminant dibenzo[def,p]chrysene

Flavin-containing monooxygenase : metabolism and toxicity of anti-tuberculosis drug ethionamide in lung

Flavin-containing monooxygenase, tissue specific regulation in rabbit

Mechanisms of inhibition of chemical carcinogenesis by indole-3- carbinol in the rat

Dehydroepiandrosterone carcinogenesis and tumor modulating effects in trout

Developmental and dietary regulation of flavin-containing monooxygenase

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