Index Catalog // ScholarsArchive@OSU

Creator:: Katchamart, Sirinmas
Abstract:: Indole-3-carbinol (I3C), the most abundant metabolite of glucobrassicins, is found in cruciferous vegetables such as broccoli, Brussels sprouts, cabbage and cauliflower. I3C has been shown to have anticarcinogenic activity against many chemical carcinogens in multiple target organs in animal models. However, the anticarcinogenic activity of I3C is considered indirect since...
Resource Type:: Dissertation
Full Text:: monooxygenases such as N, N-dimethylaniline, nicotine and tamoxifen. In liver micro somes from rats fed 13C or

Creator:: Tilton, Susan C.
Abstract:: Indole-3-carbinol (I3C) and 3,3'-diindolylmethane (DIM), a primary I3C derivative in vivo, are known chemopreventive agents available as dietary supplements. I3C was found to suppress or enhance tumors in several animal models. Chemoprotection is attributed to the ability of indoles to alter carcinogen metabolism effectively blocking initiation. However, mechanisms for enhancement...
Resource Type:: Dissertation
Full Text:: guidelines. Juvenile trout, 12-18 months old, were maintained in separate 375-L tanks (n=2 tanks) for each

Creator:: Oganesian, Aram
Abstract:: There is plenty of evidence from epidemiology studies supporting a link between certain components in the human diet and cancer incidence. It is estimated that 3-4 million annual cases of cancer could be prevented worldwide just by changing dietary habits. In parts of the world where vegetables and fruits constitute...
Resource Type:: Dissertation
Full Text:: 0.5% dietary I3C, following treatment with N-methyl-N'-nitro-N- nitrosoguanidine (MNNG), on the

Creator:: Su, Shelley A. Larsen
Resource Type:: Dissertation
Full Text:: tissue only. In 1977 Devereux et al. observed differential rates of dimethylaniline N-oxidation in pig

Creator:: Orner, Gayle A.
Resource Type:: Dissertation
Full Text:: enhancement by DHEA was not limited to AFB i-initiated hepatocarcinogenesis. DHEA treatment of N-methyl-N

Creator:: Carlson, David B., 1970-
Abstract:: Numerous natural and anthropogenic chemicals interact with endocrine systems of animals. The most widely studied of these endocrine active chemicals (EACs) are estrogen receptor agonists and antagonists. Because of the many important roles of estrogens in animals, xenoestrogens have the potential to impact environmental health. It has been proposed that...
Resource Type:: Dissertation
Full Text:: , Rivera M, Dubin N. Blood levels of organochlorine residues and risk of breast cancer. J Natl Cancer Inst

Creator:: Stresser, David M.
Resource Type:: Dissertation
Full Text:: [3H]I3C/kg body weight. 169 5.8 A) Negative CI Mass spectrum of authentic N, N-trifluoroacetylated

Creator:: Yu, Zhen
Abstract:: Lymphomas and leukemias are the most common cancer in children and young adults and in utero exposure to carcinogens may contribute to the etiology of these cancers. A polycyclic aromatic hydrocarbon (PAH), dibenzo[a,l]pyrene (DBP), was administered to pregnant mice (15 mg/Kg b.w., gavage) on gestation day 17. Significant mortalities in...
Resource Type:: Dissertation
Full Text:: , tumors were stained and analyzed by immunohistochemistry (n20) and by flow cytometry (n=4) and were

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