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Filtering by: Has journal Molecular Therapy - Nucleic Acids Remove constraint Has journal: Molecular Therapy - Nucleic Acids Advisor Zabriskie, T. Mark Remove constraint Advisor: Zabriskie, T. Mark Committee Member Mahmud, Taifo Remove constraint Committee Member: Mahmud, Taifo

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  • Advanced studies on cyclic amino acids in neurological signaling and peptide antibiotics

    Creator:
    Blanchard, David, L.
    Abstract:
    L-pipecolic acid (L-PA) is the higher homolog of proline. It occurs naturally in many organisms, including primates, as an intermediate in lysine degradation. The pathway by which lysine is converted into L-pipecolic acid employs the enzyme Lpipecolate oxidase (L-PO), and appears to be tissue specific to the central nervous system...
    Resource Type:
    Dissertation
    Full Text:
    18, 2008. Title: Advanced Studies on Cyclic Amino Acids Involved in GABAergic Neurotransmission

  • Activation, incorporation and modification of capreomycidine during viomycin biosynthesis

    Creator:
    Fei, Xiaobo
    Abstract:
    Molecular genetic and enzymological techniques have been employed to study antibiotic biosynthesis. The nonproteinogenic amino acid capreomycidine is the signature residue found in the tuberactinomycin family of antitubercular peptide antibiotics and an important element of the pharmacophore. Recombinant VioG, a single module peptide synthetase from the viomycin gene cluster cloned...
    Resource Type:
    Masters Thesis
    Full Text:
    Assembly The assembly of amino acids to form NRPs is a nucleic acid template- independent process, and