Index Catalog // ScholarsArchive@OSU

Development and in vivo testing of a gastric retention device (GRD) in dogs

Creator:: Kapsi, Shivakumar G.
Abstract:: This thesis describes 1) development of a gastric retention device (GRD) to increase gastric retention time of certain drugs, 2) product formulations of an immediate release itraconazole and controlled-release ketoprofen. GRD was fabricated from crosslinked carbohydrate polymers. Rate and extent of hydration of the film in water and in simulated...
Resource Type:: Dissertation
Full Text:: Testing of a Gastric Retention Device (GRD) in dogs, 2) Product Formulations and In Vitro-In Vivo

Evaluation of gastrointestinal transit time and novel oral acetaminophen product formulation

Creator:: Hossain, Mohammad
Abstract:: Gastrointestinal (GI) transit data were collected using pigs as animal models. Density and size effects of non-disintegrating dosage forms on GI transit were investigated. Total GI transit times range from 2 to 33 days for 22 administrations of these nondisintegrating dosage forms. Pigs are found to not be an appropriate...
Resource Type:: Dissertation
Full Text:: Novel Oral Acetaminophen Product Formulation. Abstract approved: ,Redacted for Privacy James W. Ayres

Formulation studies of lactic acid-producing bacteria for oral administration

Creator:: Liou, Yow-Hwa Grace
Abstract:: Effects of lactobacilli in enteric coated capsules were studied in piglets (Chapter I). Lactobacillus acidophilus and Lactobacillus bulgaricus isolated from a commercial product were formulated in capsules, enteric coated, and then given to both Escherichia coli-challenged and unchallenged baby pigs. Decreased incidence and severity of diarrhea, and decreased weight deceleration...
Resource Type:: Dissertation
Full Text:: Bacteria for Oral Administration Redacted for Privacy Abstract approved: Dr. Jame$ fq1. Ayres Effects of

Bioadhesive polymers in drug product formulations

Creator:: Tavipatana, Wattanaporn
Abstract:: Gastric retention time of single unit dosage forms in swine was found to be much longer than in humans. It was concluded that swine are not a good animal model to study GI transit time of nonerodable or slowly eroded dosage forms. Noneradable and slowly eroded dosage forms used to...
Resource Type:: Dissertation
Full Text:: approved: _Redacted for Privacy ((/ James W. Ayres, Ph /. / Gastric retention time of single unit dosage

Preformulation studies with 1, 3-bis (2-chloroethyl)-1-nitrosourea (NSC 409962)

Creator:: Laskar, Paul A.
Abstract:: The stability of 1 3-bis(2-chloroethyl)-1-nitrosourea (NSC 409962)(BCNU) was investigated in several buffered aqueous media, in mixed solvent and in nonaqueous solvent systems, and in the presence of several electrolytes and nonelectrolytes. The degradation rate constant of BCNU in these systems was calculated from the parameters of the linear regression of...
Resource Type:: Dissertation
Full Text:: privacy Dr. James W. All The stability of 1 3-bis(2-chloroethyl)-1-nitrosourea (NSC 409962)(BCNU) was

Calcium alginate gels in oral dosage form design

Creator:: Lin, Shun Yih
Abstract:: In vivo research following ingesting of commercially available Lactobacillus tablets, which contain about 2X10⁶ cfu/tablet of Lactobacillus acidophilus and Lactobacillus bulgaricus cells in a dose of four tablets daily, showed serum lipoprotein concentrations did not change significantly. In order to increase the number of viable Lactobacillus bacteria after challenging in...
Resource Type:: Dissertation
Full Text:: for Privacy James W. Ayres, Ph.D. In vivo research following ingesting of commercially available

The study of pharmacokinetics in a clinical environment

Creator:: Tse, Sunny
Abstract:: This dissertation presents a research series demonstrating the use of pharmacokinetic modeling and simulations as tools to assess drug concentration and disposition in patient populations. For drugs requiring therapeutic drug monitoring, these tools are necessary to ensure patients are receiving a safe and effective dose of medication to address their...
Resource Type:: Dissertation
Full Text:: . Abstract approved: James W. Ayres This dissertation presents a research series

Development and evaluation of a sustained release amoxicillin dosage form

Creator:: Ge, Yan, 1962-
Resource Type:: Masters Thesis
Full Text:: Development and evaluation of a sustained release amoxicillin

Pharmacokinetic investigation of a potential drug interaction : aminophylline and prednisone

Creator:: Anderson, John L.
Resource Type:: Masters Thesis
Full Text:: Pharmacokinetic investigation of a potential drug

In vitro and in vivo testing of a gastric retention device : development and evaluation of a new colonic delivery system

Creator:: Ahmed, Iman Saad
Abstract:: This thesis describes evaluation of a gastric retention device (GRD) developed at Oregon State University. The device was originally fabricated from Xanthan gum and Locust bean gum. A modified gastric retention device containing other additives was developed and investigated in this work. The modified device was evaluated in vitro for...
Resource Type:: Dissertation
Full Text:: . CHAPTER 1 Release and Gastric Retentive Properties of a Gastric Retention Device Iman S. Abmed and James

ScholarsArchive@OSU

Development and in vivo testing of a gastric retention device (GRD) in dogs

Evaluation of gastrointestinal transit time and novel oral acetaminophen product formulation

Formulation studies of lactic acid-producing bacteria for oral administration

Bioadhesive polymers in drug product formulations

Preformulation studies with 1, 3-bis (2-chloroethyl)-1-nitrosourea (NSC 409962)

Calcium alginate gels in oral dosage form design

The study of pharmacokinetics in a clinical environment

Development and evaluation of a sustained release amoxicillin dosage form

Pharmacokinetic investigation of a potential drug interaction : aminophylline and prednisone

In vitro and in vivo testing of a gastric retention device : development and evaluation of a new colonic delivery system

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