Index Catalog // ScholarsArchive@OSU

Part I: Total Syntheses of Mandelalide A and Isomandelalide A. Part II: Role of π-Stacking on Sharpless Dihydroxylation of cis-Enynes: Synthetic Studies Toward All Carbon Macrocyclic Mandelalide B

Creator:: Ghosh, Ankan
Abstract:: Part I of this dissertation includes the chronological synthetic background of mandelalide A as well as the synthesis of the C1-C14 glycosylated southern subunit of mandelalide. A key aspect of the synthesis includes a novel silver-catalyzed cyclization (AgCC) of a propargylic benzoate to construct the substituted cis-pyran ring system present...
Resource Type:: Dissertation

Part I: Synthetic Studies Toward Mandelalide A and Madeirolide A; Part II: Synthesis of Mandelalide/Madeirolide Hybrid Structures

Creator:: Li, Jinming
Abstract:: Mandelalide A has attracted considerable interest from the synthetic community due to its intriguing structure and important cytotoxic activity. Madeirolide A, a structurally related macrolide, shows promising antifungal activity but no appreciable anticancer activity. This dissertation describes synthetic studies toward mandelalide A, madeirolide A and their hybrid structures. Part I...
Resource Type:: Dissertation

Part I: Synthetic Studies toward C10-functionalized Lycopodium Alkaloids. Part II: Exploration of the Pummerer Cyclization and Its Application to the Total Syntheses of the Abietane Diterpenoids

Creator:: Li, Xin
Abstract:: This dissertation is separated into two parts according to the two major distinct research projects. In Part I, the full account of synthetic studies toward C10-functionalized lycopodium alkaloids is described. In Part II, the detailed discussion on the exploration of the Pummerer cyclization methodology and its application to the total...
Resource Type:: Dissertation

Synthetic Studies towards Highly Oxygenated Furanyl Diterpenoids

Creator:: Goswami, Subir
Abstract:: The furanyl diterpenoid family of natural products has drawn the attention of both synthetic organic chemists and pharmacologists due to their complex structural architectures and diverse biological activity. Among them, wortmannin has been most extensively studied for biological activities. All these furanyl diterpenoids consist of a highly strained naptha[1,8-bc]furan core,...
Resource Type:: Dissertation

Part I: Synthetic Studies Towards Viridin, Halenaquinone, and Obtusanal. Part II: Analysis, Synthesis, and Characterization of Coronene Derivatives.

Creator:: Waldenmaier, Pieter K.
Abstract:: This thesis is separated into three distinct projects. First, synthetic studies towards the furanosteroid viridin shown in part I. Second, synthetic studies towards the diperene obtusanal shown in part II. Third, the analysis, characterization, and synthesis of coronene derivatives towards their application in organic batteries shown in part III. Significant...
Resource Type:: Dissertation

Enantioselective Total Syntheses of Quinolizidine Lycopodium Alkaloid Cermizine D and Cytotoxic Marine Macrolide Mandelalide A

Creator:: Veerasamy, Nagarathanam
Abstract:: The enantioselective total synthesis of quinolizidine-containing natural product cermizine D and formal syntheses of senepodine G and cermizine C has been achieved. These natural products are members of the lycopodium alkaloids, which have attracted significant attention due to their exciting biological activities and the diverse structural scaffolds. Key steps in...
Resource Type:: Dissertation

A unified approach for the total synthesis of C₁₀-functionalyzed Lycopodium alkaloids

Creator:: Saha, Mrinmoy
Abstract:: Lycopodium alkaloids have shown widespread and noteworthy biological activity, consisting of over 250 known natural products. Moreover, their structural complexity and diversity have attracted considerable attention from numerous laboratories including our own. Recently, we have developed a unified approach that would provides access to numerous, previously unprepared C₁₀-functionalized lycopodium alkaloids....
Resource Type:: Dissertation

Synthesis, characterization, and analysis of nitroaromatic compounds

Creator:: McIntosh, Melissa Luana
Abstract:: Nitroaromatic compounds have important chemical applications and can be found in nature as pollution sources. Synthetic nitroaromatic compounds have been used in a variety of materials including explosives, pharmaceuticals, dyes, plastics, and pesticides. These compounds can find their way into the environment through normal or improper disposal methods. Poly-aromatic compounds...
Resource Type:: Masters Thesis

Himeradine A : synthetic efforts towards himeradine A and related natural products, a Michael reaction focused approach

Creator:: Collett, Nathan D.
Abstract:: Lycopodium alkaloids have generated enormous amounts of interest from the scientific community, both as synthetic targets and for their medicinal properties. Herein is described work towards a unifying approach to large segments of the Lycopodium family. An organocatalyzed intramolecular heteroatom Michael reaction method, for the construction of piperidine and piperizine...
Resource Type:: Dissertation

Part I: Total synthesis of marine macrolide amphidinolide F and synthetic studies toward amphidinolide C; Part II: Computational study on proline sulfonamide-catalyzed aldol reaction

Creator:: Mahapatra, Subham
Abstract:: More than 30 members of the diverse amphidinolide family of biologically active macrolides have been isolated over last three decades. From this family, amphidinolides C and F stand among the most complex and densely functionalized affiliates. Recently, we have accomplished the first total synthesis of amphidinolide F. The all-carbon framework...
Resource Type:: Dissertation

ScholarsArchive@OSU

Part I: Total Syntheses of Mandelalide A and Isomandelalide A. Part II: Role of π-Stacking on Sharpless Dihydroxylation of cis-Enynes: Synthetic Studies Toward All Carbon Macrocyclic Mandelalide B

Part I: Synthetic Studies Toward Mandelalide A and Madeirolide A; Part II: Synthesis of Mandelalide/Madeirolide Hybrid Structures

Part I: Synthetic Studies toward C10-functionalized Lycopodium Alkaloids. Part II: Exploration of the Pummerer Cyclization and Its Application to the Total Syntheses of the Abietane Diterpenoids

Synthetic Studies towards Highly Oxygenated Furanyl Diterpenoids

Part I: Synthetic Studies Towards Viridin, Halenaquinone, and Obtusanal. Part II: Analysis, Synthesis, and Characterization of Coronene Derivatives.

Enantioselective Total Syntheses of Quinolizidine Lycopodium Alkaloid Cermizine D and Cytotoxic Marine Macrolide Mandelalide A

A unified approach for the total synthesis of C₁₀-functionalyzed Lycopodium alkaloids

Synthesis, characterization, and analysis of nitroaromatic compounds

Himeradine A : synthetic efforts towards himeradine A and related natural products, a Michael reaction focused approach

Part I: Total synthesis of marine macrolide amphidinolide F and synthetic studies toward amphidinolide C; Part II: Computational study on proline sulfonamide-catalyzed aldol reaction

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