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Filtering by: Creator Cid, Luis Serrano Contributor advisor sim Hagen, Tory M.

A role for ceramide accumulation in age-related cardiac mitochondrial dysfunction

Creator:

Monette, Jeffrey S.

Abstract:

Ceramides are a group of lipids in the sphingolipid family that are potent cell signaling molecules. Elevations in ceramide levels above the norm generally lead to apoptosis. Evidence from in vitro studies suggests that accumulation of ceramides within mitochondria leads to dysfunction of the mitochondria. This includes inhibition of the...

Resource Type:

Dissertation

Full Text:

members of the Hagen lab: Luis Gómez, Régis Moreau, Kevin Dunn, Judy Butler, Du Heath, Liam Finlay, Kate
Age-related decrease in resilience against acute redox cycling agents: Critical role of declining GSH-dependent detoxification capacity

Creator:

Thomas, Nicholas O.

Abstract:

Over the past century, life expectancy in the United States has dramatically increased leading to an increasingly aging population with people reaching, and spending more years in ‘old age’. While this unprecedented shift in population demographics represents great strides for humanity, it is not without cost. One consequence of longer...

Resource Type:

Dissertation