Index Catalog // ScholarsArchive@OSU

Characterization of vaccinia virus A12L protein : its proteolysis and functional analyses in virus replication

Creator:: Yang, Su Jung
Abstract:: In order to produce infectious virus progeny, vaccinia virus (VV) undergoes morphogenic proteolysis to regulate the structural rearrangements of virus particles. Several of the major structural precursor proteins of VV are cleaved at a conserved Ala-Gly-X (where X is any amino acid) motif by the VV I7L core protein proteinase...
Resource Type:: Dissertation
Full Text:: virions. The open reading frame (ORF) of A12L contains two more AG/X (AG/K) sites, however, cleavage at

Disulphide bond formation is essential for vaccinia virus late protein L1R function and for production of infectious progeny

Creator:: Blouch, Robert Edward
Abstract:: L1R, a myristylated late gene product of vaccinia virus, is essential for formation of infectious intracellular mature virions (IMV). In its absence, only viral particles arrested at an immature stage are detected and no infectious progeny virus are produced. Previous studies have shown that the L1R protein is exclusively associated...
Resource Type:: Masters Thesis
Full Text:: Jennifer Yoder for her friendship, advice, proofreading, hard work keeping the Hruby lab running

Creation of an efficient protein expression and secretion system in the gram-positive bacterial vector, Streptococcus gordonii

Creator:: Myscofski, Dawn M.
Abstract:: Streptococcus gordonii (S. gordonii) is being developed as a Gram-positive expression vector for the expression of heterologous proteins. This bacterial expression system takes advantage of the natural pathway of protein export and anchoring on the surface of the bacterium. The expression of heterologous proteins relies on the homologous recombination of...
Resource Type:: Dissertation
Full Text:: Radhika Viyasanker for her helpful conversations and assistance, and Jennifer Duncan for her

Evaluation of a potential Chylamydia psittaci vaccine candidate using recombinant vaccinia virus encoding the infection-specific C. psittaci GPIC proteins IncA and TroA

Creator:: Werth, Eric P.
Abstract:: Members of the family Chlamydiae cause a wide range of diseases. Chlamydia trachomatis and C. pneumoniae are most commonly associated with human disease. C. psittaci and C. pecorum are largely animal pathogens, although C. psittaci can cause pneumonia in the elderly and immunocompromised. A vaccine against these pathogens is desirable,...
Resource Type:: Masters Thesis
Full Text:: Blouch, Wendy Brown, Jennifer Duncan, Lena Gerwick, Laurel Hall, Scott Hansen, Jennifer Lenart, Dawn

The rpsL gene and streptomycin resistance in Streptococcus gordonii and Streptococcus pyogenes

Creator:: Vidyasanker, Radhika
Abstract:: Streptomycin resistance in both gram-positive and gram-negative bacteria is usually caused by a single mutation in the rpsL gene. The rpsL gene encodes the S12 protein of the ribosomal complex. The rpsL genes of various bacteria have consensus regions in their sequences. Primers were designed from these consensus pockets and...
Resource Type:: Masters Thesis
Full Text:: appreciation to Jennifer Duncan, Scott Hansen and past and present members of my lab for making our lab so

Investigation of the roles of viral proteinases in the vaccinia virus life cycle

Creator:: Page, Jessica M.
Abstract:: An inducible, mutant virus, designated vvtetO:I7L/G1L, was used to study the morphogenic proteolysis step of the vaccinia virus life cycle. The vvtetO:I7L/G1L controlled the expression of two genes, I7L, a cysteine proteinase, and G1L, a putative metalloproteinase. These proteins are involved in the maturation of viral core proteins, p4a, p4b,...
Resource Type:: Honors College Thesis
Full Text:: research, especially Dr. Dennis Hruby, Megan Moerdyk, Dr. Chelsea Byrd, Kady Honeychurch, Jennifer Yoder

Advances in expression of heterologous protein products by Streptococcus gordonii

Creator:: Warren, Travis Kent
Abstract:: Streptococcus gordonii is a bacterial species that naturally colonizes the oral cavity of most healthy humans. It resides in the mouth as an adherent to dental surfaces and, with few exceptions, does not cause disease in individuals it inhabits. It possesses qualities that encourage its use as a vector to...
Resource Type:: Dissertation
Full Text:: AN ABSTRACT OF THE DISSERTATION OF Travis K. Warren for the

Structure-function analysis of the vaccinia virus I7L proteinase

Creator:: Moerdyk, Megan J.
Abstract:: Vaccinia virus is the prototypic member of the Orthopoxvirus genus. It undergoes a complex replication process where a key step in the transition from immature virion to intracellular mature virion is the cleavage of the major core protein precursors. The product of the I7L open reading frame (ORF) is a...
Resource Type:: Masters Thesis
Full Text:: ; Jennifer Yoder for all of her work to keeping the lab running smoothly; and Su-Jung Yang, Dina Alzhonova

Identification of intracellular trafficking signals contained within the vaccinia virus F13L protein

Creator:: Honeychurch, Kady M.
Abstract:: The F13L protein is the major envelope antigen of vaccinia virus, the prototypic member of the Orthopoxvirus genus. F13L is 372 residues in length and is essential for the formation of wrapped forms of virus. F13L contains a number of potential functional domains including a palmitylation site, a phospholipase domain...
Resource Type:: Dissertation
Full Text:: , particularly Jennifer Yoder, my sounding board, Marika Hedengren-Olcott, my partner in late-night G1L

Vaccinia virus I7L core protein proteinase

Creator:: Byrd, Chelsea M.
Abstract:: Vaccinia virus (VV) is a large double-stranded DNA virus that is a prototypic member of the orthopoxvirus family. Previous works has showed that three of the major structural proteins found within the mature VV virion core 4a, 4b, and 25K are produced from higher molecular weight precursors at late times...
Resource Type:: Dissertation
Full Text:: when experiments didn't work and celebrated when they did; Jennifer Yoder, Robert Blouch, Kady

ScholarsArchive@OSU

Characterization of vaccinia virus A12L protein : its proteolysis and functional analyses in virus replication

Disulphide bond formation is essential for vaccinia virus late protein L1R function and for production of infectious progeny

Creation of an efficient protein expression and secretion system in the gram-positive bacterial vector, Streptococcus gordonii

Evaluation of a potential Chylamydia psittaci vaccine candidate using recombinant vaccinia virus encoding the infection-specific C. psittaci GPIC proteins IncA and TroA

The rpsL gene and streptomycin resistance in Streptococcus gordonii and Streptococcus pyogenes

Investigation of the roles of viral proteinases in the vaccinia virus life cycle

Advances in expression of heterologous protein products by Streptococcus gordonii

Structure-function analysis of the vaccinia virus I7L proteinase

Identification of intracellular trafficking signals contained within the vaccinia virus F13L protein

Vaccinia virus I7L core protein proteinase

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