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Filtering by: Committee Member Pearson, G. D. Contributor advisor sim Mathews, Christopher K. Committee Member Baird, William M.

Precursors for mitochondrial DNA replication : metabolic sources and relations to mutagenesis and human diseases

Creator:

Song, Shiwei

Abstract:

It is well known that the mitochondrial genome has a much higher spontaneous mutation rate than the nuclear genome. mtDNA mutations have been identified in association with many diseases and aging. mtDNA replication continues throughout the cell cycle, even in post-mitotic cells. Therefore, a constant supply of nucleotides is required...

Resource Type:

Dissertation

Full Text:

research. My sincere appreciation also extends to the members of my committee, Drs. George D. Pearson