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Filtering by: Contributor advisor sim Stevens, Jan Subject Prodrugs

Ascorbylation- the biological relevance of covalently bound ascorbic acid

Creator:

Kesinger, Nicholas G.

Abstract:

Ascorbic acid, or vitamin C, is well known as a co-factor for proline-hydroxylase and as an anti-oxidant. However, it is also capable of forming covalent bonds, particularly in the role of a nucleophile, henceforth termed 'ascorbylation'. The ascorbylation of electrophiles can occur under physiological conditions. Furthermore, there are a number...

Resource Type:

Dissertation