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MicroRNAs miR-221 and miR-181c regulation of liver tumor growth and metastasis in mouse progeny from Dibenzo[def,p]chrysene dosed mothers fed a sulforaphane diet

Creator:

Meedom, Chelsea, Siddens, Lisbeth K., Löhr, Christiane V., and Williams, David E.

Abstract:

Dibenzo[def,p]chrysene (DBC) is a polycyclic aromatic hydrocarbon (PAH) and an IARC classified 2A probable human carcinogen. Mouse progeny transplacentally exposed to DBC have been shown to develop lung and liver tumors, with liver tumors developing predominantly in males later in life. Sulforaphane (SFN) is an isothiocyanate that plays a crucial...

Resource Type:

Poster
LncRNA regulation in mouse lung tumor from dibenzo[def,p]chrysene induced carcinogenesis in a transplacental Nrf2 knockout mouse model

Creator:

Patel, Karan, You, Hyekyoung, Siddens, Lisbeth, and Williams, David

Abstract:

Dibenzo[def,p]chrysene (DBC) is a highly potent, but less prevalent, environmental carcinogen belonging to a class of compounds known as Polycyclic Aromatic Hydrocarbons (PAHs). They are highly ubiquitous and arise as a byproduct of natural and anthropogenic combustion processes. Previous studies have documented carcinogenic effects upon in utero exposure of PAHs....

Resource Type:

Poster