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Filtering by: Contributor advisor sim Zabriskie, T. Mark Creator Fei, Xiaobo

Activation, incorporation and modification of capreomycidine during viomycin biosynthesis

Creator:

Fei, Xiaobo

Abstract:

Molecular genetic and enzymological techniques have been employed to study antibiotic biosynthesis. The nonproteinogenic amino acid capreomycidine is the signature residue found in the tuberactinomycin family of antitubercular peptide antibiotics and an important element of the pharmacophore. Recombinant VioG, a single module peptide synthetase from the viomycin gene cluster cloned...

Resource Type:

Masters Thesis