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Filtering by: Committee Member Oliveira, Ronald A. Committee Member Adams, Ronald L.

Measuring protein metal binding via mass spectrometry : copper, zinc superoxide dismutase and amyotrophic lateral sclerosis

Creator:

Rhoads, Timothy W.

Abstract:

Amyotrophic lateral sclerosis (ALS) is a devastating disease characterized by the progressive degeneration of motor neurons. Dominantly-inherited mutations to the antioxidant enzyme Cu,Zn superoxide dismutase (SOD1) cause 3-6% of all ALS cases. The complete mechanism behind the toxicity of mutant SOD1 remains unclear, although significant evidence points to aberrant or...

Resource Type:

Dissertation

Full Text:

: Joseph S. Beckman Amyotrophic lateral sclerosis (ALS) is a devastating disease characterized by